Synthetic Route of 33332-25-1, A common heterocyclic compound, 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
INTERMEDIATE 28 Methyl 5-[(oxan-4-yl)amino]pyrazine-2-carboxylate Methyl 5-chloro-2-pyrazinecarboxylate (507mg, 2.94mmol), Et3N (1.08mL, 7.64mmol) and 4-aminotetrahydropyran (395uL, 3.82mmol) were dissolved in dioxane (5ml_) and heated in a microwave reactor at 100C for 20min. Water (50mL) and brine (25ml_) were added and the reaction mixture was extracted into EtOAc (2x100ml_), dried (MgSC>4) and concentrated in vacuo to give the title compound (236mg, 33.9%) as a yellow oil. LCMS (ES+): 238.2 [MH]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PROXIMAGEN LIMITED; ESPENSEN, Max; PATIENT, Lee; EVANS, David; SIMPSON, Iain; SAVORY, Edward; WO2014/140592; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem