The important role of

Adding a certain compound to certain chemical reactions, such as: 723286-79-1, name is tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 723286-79-1, Formula: C10H16N4O2

Procedure for step-2 :To a solution of compound A48-1 (1.29 g, 5.75 mmol) in dry THF (50 mL) was added a solution of 2.5 M ?-BuLi in hexane (2.53 mL, 6.33 mmol) at -78 C under argon. After 15 min ethyl formate (702 muL, 8.63 mmol) was added and the reaction mixture was stirred for 15 min at -78 0C. Saturated aqueous NH4Cl (150 mL) was added and the mixture was extracted with CH2CI2 (3 x 100 mL) . The combined organic layer was dried (Na2SO4) and evaporated to dryness to afford aldehyde A48-2 (1.21 g, 83%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; GRUeNENTHAL GMBH; WO2009/90055; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem