Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56423-63-3, name is 2-Bromopyrazine, A new synthetic method of this compound is introduced below., SDS of cas: 56423-63-3
Example 88CPreparation of Compound (95c) A mixture of compound (95b) (1.70 g), K2CO3 (1.87 g, 4 equiv.), Pd(Ph3P)2Cl2 (72.0 mg, 3%), and 2-bromopyrazine (1.07 g, 2 equiv.) in dioxane (18 mL) and H2O (6 mL) was degassed within an ultrasonic cleaner for 1 hr under argon protection. The mixture was heated at reflux with stirring for 3 hr. The residue was partitioned with EtOAc (80 mL) and H2O (30 mL). The EtOAc layer was washed with brine, dried on MgSO4 and purified through FCC (EtOAc/Hexanes=1/1) to give 1.5 g of compound (95c).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BIOMARIN PHARMACEUTICAL INC.; US2011/178065; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem