Synthetic Route of 186534-02-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 186534-02-1, name is 3,5,6-Trimethylpyrazine-2-carbaldehyde belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
A cyclopentanone was added sequentially to a 25O mL three-necked flask(1 OmL, 0.115mo 1),Morpholine (1 OmL, 0.114 mol), benzene 100 mL,Reflux reaction to the oil-water separator after the formation of anhydrous,The reaction solution was cooled to room temperature,Add p-methoxybenzaldehyde(13 mL, 0.115 mol), refluxed for 8 h,TLC (petroleum ether – ethyl acetate = 1: 1) detection reaction is basically complete,Slowly add 6mol / L HC1 50mL,Stirring at room temperature lh,Then add 10% NaHC03 solution 115mL,Stirring at room temperature for 30min,The solution was poured into a separatory funnel,The layers were allowed to stand, the organic layer was dried over anhydrous sodium sulfate,concentrate. Dissolved in 40 mL of absolute ethanol,Add 1.5g of Chuanxiong aldehyde (0.0lmo 1),Ice bath conditions slowly add 10% NaOH ethanol solution 5mL,Reaction about lh,TLC (petroleum ether – ethyl acetate = 2: 1) detection reaction is basically complete,The precipitate was filtered off and the precipitate was washed with absolute ethanol,Purification by silica gel column chromatography (dichloromethane: ethyl acetate = 2: 1) gave 2.01 of Z1 yellow crystals,The yield was 6 1.2%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5,6-Trimethylpyrazine-2-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Anhui University of Chinese Medicine; Hefei Medical Engineering Pharmaceutical Co., Ltd.; Hefei Enruite Pharmaceutical Co., Ltd.; Li Jiaming; He Guangwei; Zhang Yang; Huang Weijun; Zhang Yanchun; Liu Weizhong; Zuo Jian; Liu Huicai; Zhu Panhu; Wang Yujun; (14 pag.)CN106518791; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem