Electric Literature of 33332-25-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
To a solution of methyl 5-chloropyrazine-2-carboxylate (8.00 g, 46.40 mmol) in THF (100 mL) was added NaBH4 (3.51 g, 93.00 mmol) under nitrogen atmosphere and the reaction mixture was stirred at 0 C for 5 h. The reaction was quenched with water (200 mL) and extracted with ethyl acetate ( 3 x 200 mL). The combined organic layers were dried over anhydrous sodium sulfate and evaporated under reduced pressure. The residue was purified by silica gel column chromatography (Redisep-40 g, 30-40% EtOAc/n-hexane) to obtain Intermediate 112A (2.00 g, 29.80%) as a yellow solid.1H NMR (300 MHz, DMSO-d6) delta ppm 4.64 (d, J = 5.67 Hz, 2 H), 5.68 (t, J = 5.85 Hz, 1 H), 8.53 (s, 1 H), 8.72 (d, J = 1.13 Hz, 1 H). LCMS (Method-H ): retention time 0.476 min, [M+H] 145.2.
The synthetic route of Methyl 5-chloropyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem