Synthetic Route of 36070-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
5-chloropyrazine-2-carboxylic acid (15.0g) and ethyl acetate (200 ml) solution which is prepared by mixing, is reacted with a thionyl chloride (30 ml) and N,N-dimethylformamide (0.28 ml), was stirred at 55 C to 60 C for 1 hour. Concentrated within a pressure reduced to reaction mixture, by the addition of toluene concentrating operation was performed 2 times. 4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine (19.96g) and cyclopentylmethyl ether (200 ml) were mixed, to this mixture the residue obtained above in cyclopentylmethyl ether (40 ml) was added dropwise at 10 C or lower, and the reaction mixture was warmed to room temperature and stirred for 5 hours. And round the leucorrhea reaction mixture, water (600 ml) for 15 C hereinafter in the dropped at room temperature the laststraw stirring section. Taking out a solid filtering, drying the adhesive after cleaning the front and back methyl ethyl ketone 5-chloro-N-{4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}pyrazine-2-carboxamide (29g) obtained as solid.
The synthetic route of 5-Chloropyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Astellas Pharma Co. Ltd.; Takahashi, Daisuke; Maeda, Jun; Inakaki, Yusuke; Nekoro, Genji; Tanaka, Hiroaki; Yokoyama, Katsuhiro; Takamitsu, Hajime; Koike, Takanori; Tsukamoto, Itsei; (153 pag.)KR2015/120516; (2015); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem