Electric Literature of 68774-77-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68774-77-6, name is 8-Chloro[1,2,4]triazolo[4,3-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 1.28. (3 ?,4S)-4-methylbenzyl 4-(([l,2,4]triazolo[4,3-a]pyrazin-8-ylamino)methyl)-3- fluoropiperidine-l-carboxylate (E2-1.2). [0265] A mixture of 8-chloro-[l,2,4]triazolo[4,3-a]pyrazine (120 mg, 0.78 mmol), (3R,4S)-4- methylbenzyl 4-(aminomethyl)-3-fluoropiperidine-l-carboxylate hydrochloride (297 mg, 0.94 mmol) and DIPEA (0.65 mL, 3.9 mmol) in n-BuOH (4 mL) was heated to 120C under N2 atmosphere. After stirring overnight at 120C, the mixture was cooled down to room temperature and concentrated under vacuum. The concentrate was partitioned into EtOAc and water. The organic phase was washed with water, brine, dried over Na2S04 and concentrated. The concentrate was purified by column chromatography over silica gel (eluent: 100% ethyl acetate) to afford the title compound as a brown powder (187 mg, 78%). MS (ESI) calcd for C20H23FN6O2: 398.2; found: 399.3[M+H]. *H NMR (400 MHz, CD3OD) delta 9.09 (s, 1H), 7.69 (d, J = 4.8 Hz, 1H), 7.30 (d, J = 4.8 Hz, 1H), 7.24 (d, J = 8.0 Hz, 2H), 7.16 (d, J = 8.0 Hz, 2H), 5.08 (s, 2H), 4.85-4.71 (m, 1H), 4.50-4.40 (m, 1H), 4.28-4.20 (m, 1H), 3.68-3.63 (m, 1H), 3.60-3.55 (m, 1H), 3.11-3.00 (m, 1H), 2.95-2.80 (m, 1H), 2.33 (s, 3H), 2.30-2.11 (m, 1H), 1.71-1.57 (m, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 8-Chloro[1,2,4]triazolo[4,3-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon; (239 pag.)WO2016/100349; (2016); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem