Reference of 3149-28-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3149-28-8 as follows.
Alternate synthesis of (8) A solution of 5.4 ml of 2,2,6,6-tetramethylpiperidine, in 300 ml of dry THF was cooled to -8C as 19 ml of 1.6 M butyllithium (0.03 mol) in hexane was added dropwise. The reaction was stirred 20 min then cooled to -77C. A solution of 2.5 g of 2-methoxypyrazine (0.023 mol) in 5 ml of THF was added dropwise to the reaction. After 5h, 2.9 g of 3-quinuclidinone (0.023 mol) in 5 ml of THF was added dropwise and the reaction stirred another h. A solution of 8 ml of concentrated HCl and 4 ml of ethanol was added, the cooling was removed, and when the temperature reached -10C, 20 ml of 5 N NaOH was added. The volatile organics were evaporated and the residue extracted 3X with 50 ml of CHCl3 The extracts were washed with brine, dried, and the solvent evaporated to give a clear yellow liquid that solidified on further drying. Recrystallization from ether gave 3.53 g of (8) identical to the material produced in the previous reaction.
According to the analysis of related databases, 3149-28-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVO NORDISK A/S; EP521067; (1995); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem