Synthetic Route of 1049026-49-4, These common heterocyclic compound, 1049026-49-4, name is 2-Bromo-5-(methylthio)pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: To a solution of 2-bromo-5-(methylthio)pyrazine (CAS1049026-49-4, 5 g) in (0432) N,N-dimethylacetamide (10 ml) were added ethane- 1,2-diol (7.57 g) and potassium carbonate (5.05 g). The mixture was stirred at room temperature for 18 h. The mixture was heated to 60 C for 8 h and stirred at room temperature for 3 days. The mixture was heated to 90 C for 1.5 h. The temperature was raised to 100 C and the mixture was stirred for 2 h. After cooling to room temperature, water was added and the mixture was extracted with EtOAc. The organic layers were dried (MgS04), filtered and concentrated in vacuo.The crude material was purified by flash chromatography (Si02, 0% to 50% EtOAc in n-heptane) to give 2-((5-(methylthio)pyrazin-2- yl)oxy)ethanol (2.88 g) as colorless solid. MS: m/z = 187.1 [M+H]+.
Statistics shows that 2-Bromo-5-(methylthio)pyrazine is playing an increasingly important role. we look forward to future research findings about 1049026-49-4.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; SIENA BIOTECH S.P.A.; GUBA, Wolfgang; HAAP, Wolfgang; OBST SANDER, Ulrike; PETERS, Jens-Uwe; WOLTERING, Thomas; (81 pag.)WO2016/1266; (2016); A1;,
Pyrazine – Wikipedia,
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