Adding a certain compound to certain chemical reactions, such as: 109-08-0, name is 2-Methylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109-08-0, Application In Synthesis of 2-Methylpyrazine
100L enamel reaction kettle, equipped with material dropping pipe (connected with metering pump), equipped with chlorine gas introduction pipe (connected with chlorine gas automatic control system), automatic pressure control system, temperature detection chain control system. Add 96kg of solvent dichloroethane and 1kg of triethylamine to the reaction kettle and start stirring, then pass chlorine gas, and set the pressure in the kettle to be automatically controlled at 0.02-0.03MPa for 20-30 minutes. Then start feeding with a metering pump at a rate of 5kg/h (according to 10kg of methylpyrazine mixed with 10kg of dichloroethane to be used evenly), the reaction exotherm is obvious, the reaction temperature is controlled at 45 ~ 60 C , the temperature is higher than 60C. The feeding system is automatically cut off at (if necessary, the water flow can be manually controlled to lower the temperature), the beating is completed in about 4 hours, and then the reaction is continued for 30 minutes at a pressure of 0.02 ~ 0.03MPa. Then lower the temperature to 30-40C, introduce the residual chlorine gas in the reaction kettle into the lye spray absorption tower to absorb, the remaining reaction liquid in the kettle is pressed into the dichloroethane turnover tank with nitrogen through the pipeline filter (containing chlorine gas for recycling), the reaction kettle The remaining chloropyrazine hydrochloride solid is dissolved in 30Kg of water first, and then neutralized with 30% alkaline solution to pH 6-7, and then separated into layers to obtain crude chloropyrazine, about 12Kg, content about 92 % Is directly used for the next reaction.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methylpyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shandong Jitian Biological Technology Co., Ltd.; Shandong Jitian Flavors Co., Ltd.; Yang Weixiang; Ren Wei; Yang Liang; Liu Shuzeng; Zhang Hongkui; Zhao Bin; Sun Yicheng; (6 pag.)CN110963974; (2020); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem