Application of 957344-74-0, These common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5,8-dibromoimidazo[1,2-a]pyrazine (2.75 g, 9.90 mmol) prepared in step 1, cyclopropylamine (3.4mL, 49.50 mmol),N, N- diisopropylethylamine to (3.5 mL, 19.80 mmol) was dissolved in 1,4-dioxane (33 mL), the mixture at 100C stirred for 16 hours.Neutralized by addition of a saturated aqueous solution of sodium bicarbonate to the reaction solution and ethyl acetateExtracted with Tate.The extracted organic layer was washed with water. The organic layer was dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting residue was purified by column chromatography (ethyl acetate: n- hexane = 1: 1) to give the title compound (530 mg, 92%)
The synthetic route of 957344-74-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HANMI PHARM. CO., LTD.; HAM, YOUNG JIN; SON, JUNG BEOM; PARK, CHANG HEE; KANG, SEOK JONG; CHOI, JAE YUL; KIM, SEO HEE; (36 pag.)KR2015/113801; (2015); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem