Related Products of 4949-13-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4949-13-7 as follows.
STEP 1. 2-FLUORO-3-IODOPYRAZINE Butyl lithium solution (2.5 M in hexane, 881 mL, 2.01 mol) and 1.5 L of dry THF were charged into a flame-dried 5.0 L round-bottomed flask. The flask was cooled to -50 C. and 2,2,6,6-tetramethylpiperidine (312.0 mL, 2.20 mol) was added dropwise. The reaction mixture was warmed to 0 C. without taking the cold bath away and kept at that temperature for 20 min. The reaction was then cooled to -78 C., and 2-fluoropyrazine (180 g, 1.84 mol) in 150 mL of THF was added dropwise. The mixture was kept at -78 C. for 5 min. Iodine (464 g, 1.84 mol) in 500 mL of THF was added dropwise and the reaction mixture was kept at -78 C. for 1 h. The reaction was quenched with the addition of 250 mL of concentrated HCl, 250 mL MeOH and 250 mL THF at -78 C. The cold bath was then removed, and aqueous sodium bisulfite was added to get rid of traces of unreacted iodine. The solvent was then evaporated and the residue was diluted with water and adjusted to pH 8. The mixture was extracted with ethyl acetate (3*1.5 L). Combined ethyl acetate layer was dried over sodium sulfate and concentrated. The crude product was purified by column chromatography (Silica:100-200 mess, solvent: 10% EtOAc/hexanes) to give the title compound as a white solid.
According to the analysis of related databases, 4949-13-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMGEN INC.; US2010/160280; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem