Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, A new synthetic method of this compound is introduced below., category: Pyrazines
(2) To a 100 mL eggplant flask were added the yellow oil (1.65 g) prepared in the above step, 2-chloro-3-hydrazinylpyrazine (1.26 g), and diisopropylethylamine (4.56 mL) under argon gas flow, and the resulting mixture was stirred at 80 C. for 4 hours. (1716) After the reaction was completed, the mixture was concentrated under reduced pressure, water was added thereto, and the resulting mixture was extracted with ethyl acetate. The resulting organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residues were subjected to silica gel chromatography (hexane:ethyl acetate=70:30 to 50:50) using YAMAZEN medium pressure preparative (Silica L (40 g)), the fractions comprising the target compound (Rf value=0.25 (hexane:ethyl acetate=1:1)) were collected, concentrated under reduced pressure, to the resulting residues was added diisopropyl ether, the precipitated solid was filtered, and dried under reduced pressure to give the title compound (1.53 g) (yield 62%) as a white solid. (1717) MS(CI) m/z: 284/286 [M+H]+
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; UBE INDUSTRIES, LTD.; NAKAJIMA, Tatsuo; HAYASHI, Norimitsu; ISHIZAWA, Kouhei; TSUZAKI, Yasunori; IWAMURA, Ryo; TSUBOIKE, Kazunari; US2019/185479; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem