Related Products of 4774-14-5, The chemical industry reduces the impact on the environment during synthesis 4774-14-5, name is 2,6-Dichloropyrazine, I believe this compound will play a more active role in future production and life.
Step 1: N-Benzyl-6-Chloro-2-Pyrazinamine. A mixture of 2,6-dichloropyrazine (1.31 g, 8.8 mmol), benzylamine (1.15 g, 10.7 mmol) and K2CO3 (1.65 g, 11.9 mmol) in acetonitrile (6 mL) was heated at 85 C. for 13 h in a sealed pyrex flask. The reaction mixture was diluted with dichloromethane, filtered and concentrated in vacuo. The yellow solid residue was dissolved in a small volume of methanol and purified by silica gel chromatography (18*4 cm) using CHCl3/MeOH (98:2) as eluent. A second purification (SiO2;16*4 cm) using CHCl3 as eluent furnished 1.55 g (81%) of the title compound as a light yellow solid. HRMS m/z calcd for C11H10ClN3 (M)+219.0563, found 219.0568. Anal. (C11H10ClN3) C, H, N.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dichloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Nilsson, Bjorn M.; US2002/147200; (2002); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem