Synthetic Route of 243472-70-0,Some common heterocyclic compound, 243472-70-0, name is 5-Bromo-2,3-diphenylpyrazine, molecular formula is C16H11BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Trimethylamine(33% ethanol solution, 358 g, 2.0 mol) was added5-chloro-2,3-diphenylpiperazine (266 g, 1.0 mol) in ethyl acetate (1.3 L)And stirred at room temperature for 48 hours.A large number of solids are present.filter,The solid was washed with ethyl acetate (2 x 50 mL)Dried in high vacuum to give 283.5 g of a white solid,The yield was 87%.:_In the same manner as in Example 1, except that 5-bromo-2,3-diphenylpiperazine was used in place of 5-chloro-2,3-diphenylpiperazine,Preparation of 2,3-diphenylpiperazine trimethylammonium bromide with 2,3-diphenylpiperazine trimethylammonium chloride.The yield was 75%.
The synthetic route of 243472-70-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Suzhou Guohang Pharmaceutical Technology Co., Ltd.; Mei, Desheng; (11 pag.)CN106467496; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem