Electric Literature of 1111638-10-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1111638-10-8, name is 3-Chloro-5H-pyrrolo[2,3-b]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Step 4: 3-chloro-5-methyl-5H-pyrrolo[2,3-b]pyrazine To a mixture of 3-chloro-5H-pyrrolo[2,3-b]pyrazine (2.0 g, 13.02 mmol) and potassium hydroxide ( 1.46 g, 26.04 mmol) in N,N-dimethylmethanamide (40 ml . ) was added iodomethane (3.70 g, 26.04 mmol). The reaction mixture was stirred at 25 C for 3 h and diluted with water (50 mL). The mixture was extracted with ethyl acetate (3 x 100 mL). The combined organic layers were dried over sodium sulfate and concentrated to dryness in vacuo. The resulting residue was purified by column chromatography (silica gel, 100-200 mesh, 40% ethyl acetate in hexane) affording 3-chloro-5-methyl- 5H-pyrrolo[2,3-b]pyrazine (2.0 g, 92%): H NMR (400 MHz, DMSO-d6) delta 8.47 (s, 1H), 7.94 (d, J =3.6 Hz, 1H), 6.72 (d, = 3.6 Hz, 1H), 3.82 (s, 3H).
The synthetic route of 3-Chloro-5H-pyrrolo[2,3-b]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; HUESTIS, Malcolm; KELLAR, Terry; PATEL, Snahel; SHORE, Daniel; SIU, Michael; (260 pag.)WO2016/142310; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem