Synthetic Route of 21948-70-9, A common heterocyclic compound, 21948-70-9, name is 2-Methylthiopyrazine, molecular formula is C5H6N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The mixture of 2-methylthiopyrazine (120 mg, 0.95 mmol) andMeI (203 mg 1.43 mmol) was stirred in a closed vial at 80 C for 2 h.The precipitated orange powder of [MMTP]I was washed withdiethyl ether (2 Chi 8 mL) and dried under vacuum. Yield: 230 mg(90%). 1H NMR (500.13 MHz, CD3CN): delta = 9.03 (dd, JHH = 5.1, 2.8 Hz,1H, C2-H), 8.73 (s, 1H, C5-H), 8.27 (s, 1H, C6-H), 4.25 (s, 3H,Me-N), 2.69 (s, 3H, Me-S). FT-IR (KBr, cm-1): 380 (vs), 420 (w), 449(s), 528 (m), 710 (s), 746 (s), 831 (s), 874 (s), 887 (s), 955 (s), 982 (s),1003 (m), 1124 (s), 1144 (w), 1173 (m), 1221 (vw), 1240 (s), 1260 (s),1281 (s), 1317 (vs), 1439 (m), 1454 (m), 1472 (m), 1528 (s), 1611 (s),2851 (vs), 2916 (vs), 2988 (s), 3028 (s), 3051 (s), 3100 (s). Anal. Calcdfor C6H9IN2S: , 26.88; , 3.38; N, 10.45. Found: , 26.9; , 3.3; N,10.3.
The synthetic route of 21948-70-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Artem’ev, Alexander V.; Bagryanskaya, Irina Yu; Journal of Molecular Structure; vol. 1173; (2018); p. 743 – 749;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem