In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3-Bromo-8-chloroimidazo[1,2-a]pyrazine
Example 7-1 : Preparation of N-cyclopropyl-4-[8-(pentylamino)imidazo[1 ,2- a]pyrazin-3-yl]benzamide3-bromo-8-chloro-imidazo[1 ,2-a]pyrazine (intermediate example 1 -1 , 0.15 mmol, 0.75 mL, 0.2M in NMP), 1 -pentanamine (1.5 eq, 0.3 mL, 0.5 M in NMP) and DIPEA (3 eq, 77 mu) were combined in a sealed vial and heated at 160 C under microwave irradiation for 60 min. After cooling, [4-[(cyclopropylamino)carbonyl]phenyl]- boronic acid (1.5 eq, 0.45 mL, 0.5 M in NMP), Pd(dppf)Cl2 (0.1 eq, 400 mu, 0.0375 M in NMP) and potassium carbonate (450 muIota_, 1M in water) were added and the mixture was heated at 160 C under microwave irradiation for 80 min. After cooling, the solution was filtered and subjected to preparative HPLC to give N- cyclopropyl-4-[8-(pentylamino)imidazo[1 ,2-a]pyrazin-3-yl]benzamide (3.8 mg, 7 %): UPLC-MS: RT = = 0.83 min; m/z (ES+) 364.5 [MH+]; required MW = 363.5
The synthetic route of 143591-61-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard; WO2012/80229; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem