In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 32974-92-8 as follows. category: Pyrazines
To a solution of 6 g (40 mmol) 1-(3-Ethyl-pyrazin-2-yl)-ethanone in 21 ml HBr (33%) and 7 ml methanol was added 2 ml (40 mmol) bromine and the mixture was heated to 60 C for 3 h. After removal of the volatiles under reduced pressure the residue was washed with diethyl ether and ethyl acetate. 6.4 g (41%) of the title compound was obtained as grey solid. MS (m/e): 229.1 (M+H, 100%).
According to the analysis of related databases, 32974-92-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. Hoffmann-La Roche AG; WO2004/14884; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem