Reference of 957344-74-0, The chemical industry reduces the impact on the environment during synthesis 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, I believe this compound will play a more active role in future production and life.
Step 1 (5-Bromo-iotamiotadazo[ 1 , 2-a]pyraziotan-8-yl)-(4-methanesulfonyl-phenyl) -amine[00270] A degassed mixture of 5,8-dibromo-imidazo[l,2-a]pyrazme (2.19g, 7.916mmol), A- methylsulfonylamlme (1 49g, 8.708mmol), Pd2dba3 (145mg, 0.15mmol) and Xantphos (183mg, 0.317mmol), m dry toluene (5OmL) is stirred at 1100C for 16 hours. After evaporation of the solvent, the residue is purified by silica gel column chromatography elutmg with 95:5 DCM:NH3 (7M in MeOH). The title compound (1.496g, 51%) is isolated containing some starting material (20%) and used in the next step without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,8-Dibromoimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem