Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68774-77-6, name is 8-Chloro[1,2,4]triazolo[4,3-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 68774-77-6
Step 1. (3S, 4 ?)-tert-butyl 4-(([l,2,4]triazolo[4,3-o]pyrazin-8-ylamino)methyl)-3- fluoropiperidine-l-carboxylate [0187] A mixture of 8-chloro-[l,2,4]triazolo[4,3-a]pyrazine (2.00 g, 12.94 mmol), (3S, 4 ?)-tert-butyl 4- (aminomethyl)-3-fluoropiperidine-l-carboxylate (2.86 g , 12.32 mmol) and DIPEA (4.07 mL, 24.64 mmol) in n-butyl alcohol (40 mL) was heated to 120 C in the sealed tube under N2 atmosphere. After stirring overnight, the mixture was cooled to rt and concentrated under reduce pressure. The concentrate was partitioned into DCM and water. The organic phase was washed with water, brine, dried over Na2S04 and concentrated. The concentrate was purified by column chromatography over silica gel (MeOH/DCM = 1/20) to afford the title compound as a pale-yellow powder (2.91g, 67%). MS (ESI) calcd for C16H23FN602: 350.2; found: 351.7[M+H]. *H NM (400 MHz, CD3OD) delta 9.09 (s, 1H), 7.70 (d, J = 4.8 Hz, 1H), 7.31 (d, J = 4.8 Hz, 1H), 4.86-4.73 (m, 1H), 4.42-4.35 (m, 1H), 4.19-4.16 (m, 1H), 3.67-3.62 (m , 1H), 3.59-3.54 (m, 1H), 3.05-2.74 (m, 2H), 2.25 -2.10 (m, 1H), 1.67-1.53 (m, 2H), 1.46 (s, 9H).
According to the analysis of related databases, 68774-77-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon; (239 pag.)WO2016/100349; (2016); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem