Electric Literature of 59303-10-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59303-10-5, name is 2-Chloro-5-methylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 4-((lr,4r)-4-(4-(methylsulfonyl)phenoxy)cyclohexyloxy)piperidine hydrochloride (24.2 mg, 0.062 mmol), 2-chloro-5-methylpyrazine (90 mg, 0.700 mmol), and triethylamine (40 mu, 0.287 mmol) in iPrOH (1 mL) was heated under microwave irradiation at 200 C for 5 h. The mixture was concentrated and the residue was purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (8.7 mg) as a white solid. LCMS m/z = 446.2 [M+H]+; .H NMR (400 MHz, CDC13) delta 1.46-1.68 (m, 6H), 1.89-1.96 (m, 2H), 1.99- 2.04 (m, 2H), 2.10-2.15 (m, 2H), 2.39 (s, 3H), 3.03 (s, 3H), 3.21-3.27 (m, 2H), 3.55-3.59 (m, IH), 3.63-3.67 (m, IH), 3.91-3.97 (m, 2H), 4.39-4.44 (m, IH), 6.98-7.01 (m, 2H), 7.83-7.86 (m, 2H), 7.94 (s, IH), 8.07 (s, IH).
The synthetic route of 2-Chloro-5-methylpyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; BUZARD, Daniel J.; LEHMANN, Juerg; NARAYANAN, Sanju; YUE, Dawei; WO2011/127051; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem