Reference of 87486-34-8, These common heterocyclic compound, 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 12 L threenecked RBF equipped with an overhead stirrer and reflux condenser was chargedsequentially with (-)-1,4-dimethyl-3-(4-aminophenyl)piperazin-2-one (V, 491 g, 2.24 mol), 3,5-dibromo-1-methylpyrazin-2(1H)-one (VI, 600 g, 2.24 mol), i-PrOH (5 L) and triethylamine (350mL, 2.5 mol). The resulting suspension was heated at 82 °C for 24 h (Caution: reaction was exothermic).After the reaction mixture was cooled for 5 h, 1.25 L of 2 M Na2CO3solution was added and the suspension was stirred overnight. The orange solids were then collected on afritted funnel and washed with 2 L of fresh IPA (color was washed off). The resulting tan solids were suspended in 3L of deionized water and stirred at 25 °C for 1 h. After filtration, the solids were washed with1 L of methyl tert-butyl ether (MTBE)and dried under vacuum in the funnel at 25 °C for 1 h and in an amber glass at40 °C overnight. White solids wereobtained as compound VII (629 g, 69percent).
Statistics shows that 3,5-Dibromo-1-methylpyrazin-2(1H)-one is playing an increasingly important role. we look forward to future research findings about 87486-34-8.
Reference:
Article; Young, Wendy B.; Barbosa, James; Blomgren, Peter; Bremer, Meire C.; Crawford, James J.; Dambach, Donna; Gallion, Steve; Hymowitz, Sarah G.; Kropf, Jeffrey E.; Lee, Seung H.; Liu, Lichuan; Lubach, Joseph W.; Macaluso, Jen; Maciejewski, Pat; Maurer, Brigitte; Mitchell, Scott A.; Ortwine, Daniel F.; Di Paolo, Julie; Reif, Karin; Scheerens, Heleen; Schmitt, Aaron; Sowell, C. Gregory; Wang, Xiaojing; Wong, Harvey; Xiong, Jin-Ming; Xu, Jianjun; Zhao, Zhongdong; Currie, Kevin S.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 6; (2015); p. 1333 – 1337;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem