Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H3ClN2O2
5-Chloropyrazine-2-carboxylic acid [CAS RN: 36070-80-1] (420 mg, 2.65 mmol,1.0 eq) was dissolved in 10 mL THF, and CDI (430 mg, 2.65 mmol, 1.0 eq) was added. Then, the reaction mixture was heated to 75C for 45 mm. On cooling the resulting solution was added dropwise to a solution of tert-butyl methyl[2- (methylamino)ethyl]carbamate [CAS-RN: 112257-19-9] (513 mg, 2.73 mmol,1.03 eq) in 3 mL THF. The reaction mixture was stirred at 70C for 60 mm. Thevolatile components were removed in vacuo and the crude material was purified via preparative MPLC (Biotage Isolera; 25 g SNAP cartridge: hexane -> hexane/ethyl acetate 2/1 -> hexane/ethyl acetate 2/3) to give 322 mg (37% yield of theory) of the title compound.UPLC-MS (Method 1): R = 1 .07 mm; MS (EI0): m/z = 329 [M+H].
According to the analysis of related databases, 36070-80-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem