Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 486460-20-2, name is 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H3F3N4
A mixture of 250 mg (1.33 mmol) of 3-(trifluoromethyl)[l,2,4]triazolo[4,3-a]pyrazine(Intermediate 6, Step A), 0.479 mL (4.66 mmol) of 30% hydrogen peroxide aqueous solution, and 2 mLof glacial acetic acid was stirred at 95 C. After 8 h, the solution was cooled and concentrated. Theresidue was partitioned between dichloromethane and saturated sodium bicarbonate aqueous solution.Thin-layer chromatography on silica gel (90:10:1 dichloromethane:methanol:concentrated ammoniumhydroxide solution) revealed that the product was in the aqueous phase. Therefore, the aqueous solutionwas concentrated to dryness, and the residue was purified by preparative HPLC (C18 reverse phasecolumn, 0-50% acetonitrile in water containing 0.05% trifluoroacetic acid) to provide the title compoundas a white solid. LC-MS 205 (M+l).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 486460-20-2.
Reference:
Patent; MERCK & CO., INC.; WO2006/23750; (2006); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem