Electric Literature of 330786-09-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 330786-09-9, name is Methyl 3,5-dichloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of methyl 3,5-dichloropyrazine-2-carboxylate (100 mg, 0.483 mmol) in dioxane (1.93 mL) were added tert-butyl (4-methylpiperidin-4-yl)carbamate (109 mg, 0.507 mmol) and TEA (0.141 mL, 1.01 mmol) and the resulting mixture was stirred at 24 C for 18 h. H20 (20 mL) was added, and the layers were separated. The aqueous phase was extracted with EtOAc (3 x 20 mL), the combined organic layers were washed with sat NaCl, dried over Na2S04, filtered and concentrated under reduced pressure. The residue was purified via silica gel chromatography (0 – 100 % EtOAc in hexanes) to give the title compound (120 mg, 64%) as pale yellow solid. MS (ES+) C17H25CIN4O4 requires: 384, found: 407 [M+Na]+. ‘H NMR (500 MHz, Chloroform-c d 7.88 (s, 1H), 4.40 (s, 1H), 3.96 (s, 3H), 3.71 – 3.57 (m, 2H), 3.46 – 3.27 (m, 2H), 2.19 – 2.04 (m, 2H), 1.74 – 1.62 (m, 2H), 1.54 – 1.34 (m, 12H). Also isolated regioisomer methyl 5-(4-((tert-butoxycarbonyl)amino)-4-methylpiperidin-l-yl)-3- chloropyrazine-2-carboxylate (60 mg, 32%) as a pale yellow solid. 1 H NMR (500 MHz, Chloroform-c ) d 8.03 (s, 1H), 4.41 (s, 1H), 4.06 – 3.96 (m, 2H), 3.95 (s, 3H), 3.53 – 3.39 (m, (0708) 2H), 2.26 – 2.12 (m, 2H), 1.72 – 1.57 (m, 2H), 1.50 – 1.37 (m, 12H).
The chemical industry reduces the impact on the environment during synthesis Methyl 3,5-dichloropyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; JONES, Philip; CROSS, Jason; BURKE, Jason; MCAFOOS, Timothy; KANG, Zhijun; (154 pag.)WO2019/213318; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem