Reference of 27825-21-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Methyl 3-chloropyrazine-2-carboxylate (504 mg, 2.9 mmol, 1 eq.), O-benzylhydroxylamine (1073 mg, 8.72 mmol, 3 eq.), Dimethyl sulfoxide (3 mL) and N,N-diisopropylethylamine (1.44 mL, 8.72 mmol, 3 eq.) were added to a microwave reaction tube, and microwave reaction was performed at 100 C for one hour. After the reaction, the reaction solution was transferred to a separating funnel, 30 mL of ethyl acetate and 30 mL of a saturated sodium chloride solution were added, the organic phase was separated, and the aqueous layer was extracted twice with ethyl acetate. The organic phases were combined, dried over anhydrous magnesium sulfate, filtered, and the filtrate was concentrated and sampled with 100-200 mesh silica gel. After purification by 200-300 mesh silica gel column chromatography (eluent EA: PE = 1: 4), crude intermediate 2 was obtained. The crude product was recrystallized from petroleum ether / n-hexane to obtain intermediate 3-((benzyloxy)amino)pyrazine-2-carboxylic acid methyl ester (2, yield: 16%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-chloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shandong University; Liu Xinyong; Sun Lin; Zhan Peng; Gao Ping; Cheng Xiqiang; Li Yanqi; Wang Xueshun; (24 pag.)CN108299428; (2019); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem