Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 28643-16-5, name is Methyl 3-amino-5-chloropyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 3-amino-5-chloropyrazine-2-carboxylate
a) 3-Amino-5-vinyl-pyrazine-2-carboxylic acid methyl ester To a mixture of 3-amino-5-chloro-pyrazine-2-carboxylic acid methyl ester (GB 1248146, 161 mg 0.86 mmol), tributyl(vinyl)tin (0.352 ml, 1.204 mmol) and lithium chloride (102 mg, 2.498 mmol) in DMF (4 ml) was added PdCI2(PPh3)2 (30.2 mg, 0.043 mmol) and the mixture was heated to 85 C for 2.5 h. After cooling to room temperature water was added and the mixture was extracted with EtOAc, the combined organic layers were washed with water and half saturated aq. NaCI, dried with Na2S04 and evaporated. The residue was purified by chromatography on silica gel (cyclohexane to cyclohexane/EtOAc 1 :9) to provide the title compound as yellow solid. HPLC: RtH4= 0.71 min; ESIMS [M+H]+ = 179.9; 1H-NMR (600 MHz, DMSO-c 6): delta 8.04 (s, 1 H), 7.35 (br. s, 1 H), 6.75 (dd, 1 H), 6.38 (d, 1 H), 5.70 (d, 1 H), 3.84 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NOVARTIS AG; LUEOEND, Rainer Martin; MACHAUER, Rainer; RUEEGER, Heinrich; VEENSTRA, Siem Jacob; WO2013/27188; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem