Electric Literature of 313339-92-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 313339-92-3 name is 3,5-Dichloropyrazine-2-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2,3-dichloro-N-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]benzenesulfonamide (5.78 g) and 3,5-dichloro – pyrazine-2-carbonitrile (2.35g), 1,1′- bis (diphenylphosphino) ferrocene – dichloropalladium (II) (Pd (dppf) 2Cl2) (791mg) and cesium carbonate (13.2g) was added to a reaction vessel equipped with a magnetic stir bar, then add 100ml of dioxane and 10ml water, stirring the mixture was heated to 100 c for 3h the reaction mixture was cooled to room temperature and treated with saturated aqueous sodium bicarbonate (lml) quenched and extracted with EtOAc (3 X 200ml). the combined aqueous phases were dried over sodium sulfate, filtered and evaporated to give the crude product as a brown oil. using EtOAc and purified by silica gel chromatography using heptane as eluent fast, the solvent was evaporated the solvent under reduced pressure to give a light brown foam 2,3-dichloro-N-[4-(6-chloro-5-cyanopyrazin-2-yl)phenyl]benzenesulfonamide yield:. 4ยท32g (73%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dichloropyrazine-2-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Sanofi; Nazare, M; HALLAND, N; SCHMIDT, F; WEISS, T; Dietz, U; Hofmeister, A; (76 pag.)CN103012407; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem