Application of 51171-02-9, These common heterocyclic compound, 51171-02-9, name is Methyl 3-Bromo-2-pyrazinecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(a) 3-(4-chlorophenylamino)-pyrazine-2-carboxylic acid methyl ester A mixture of 21.7 g 3-bromo-pyrazine-2-carboxylic acid methyl ester and 25.5 g 4-chloroaniline in 150 ml ethyl acetate is boiled 4 days at reflux. The solution is washed with 4 N hydrochloric acid, water and then with 2 N sodium carbonate. The organic phase is dried over sodium sulphate and evaporated to give the heading compound (recrystallized from isopropanol) m.p. 135-136.
Statistics shows that Methyl 3-Bromo-2-pyrazinecarboxylate is playing an increasingly important role. we look forward to future research findings about 51171-02-9.
Reference:
Patent; Sandoz Ltd.; US4337198; (1982); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem