Adding a certain compound to certain chemical reactions, such as: 19745-07-4, name is 2,5-Dichloropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19745-07-4, Quality Control of 2,5-Dichloropyrazine
A solution of 2,5-dichloropyrazine (217 mg, 1.46 mmol), tert-butyl ((3S,4S)-3- hydroxypiperidin-4-yl)carbamate (300 mg, 1.387 mmol) and K2CO3 (575 mg, 2.25 mmol) in DMSO (2.3 mL) was stirred at 90 °C for 12 h, then at room temperature overnight. The reaction was diluted with water (15 mL) and extracted with DCM (3 x 15 mL). The combined organic extracts was washed with brine (15 mL), dried over anhydrous Na2S04(S), filtered, and concentrated in vacuo. The crude was purified by silica chromatography (0-15percent MeOH/DCM) followed by reverse phase chromatography (0 to 98percent MeCN/water). The fractions containing product were combined, concentrated to remove most ACN, diluted with sat. NaHCCb (15 mL) and extracted with DCM (3 x 15 mL). The combined organic extracts was washed with brine (15 mL) and dried over anhydrous Na2S04(S), filtered, and concentrated in vacuo to afford the title compound (180.7 mg, 40percent yield). MS (apci) m/z = 329.2 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dichloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem