Application of 91476-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 91476-80-1, name is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
To (3R)-tert-butyl 3-(2-(N,N-bis(4-methoxybenzyl)sulfamoyl)-4-iodo-3-(1-(4- methoxybenzyl)-1H-tetrazol-5-yl)phenylsulfonamido)pyrrolidine-1-carboxylate (REFERENCE EXAMPLE 5) (120 mg, 0.125 mmol) and 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (30.8 mg, 0.250 mmol), Cs2CO3 (122 mg, 0.375 mmol), and RAC-BINAP-Pd-G3 precatalyst (25 mg, 0.025 mmol) were added to DME (2.5 mL) at RT and the mixture was degassed for 10 min under nitrogen, stirred at 80 C overnight. The mixture was diluted with water (50 mL), extracted with EtOAc (2 x 50 mL). The combined organic phases were washed with brine, dried (MgSO4) and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with a gradient of 0 – 25% heptane/ethanol over 20 min to give the title product. LC/MS [M+H]: 955.
The synthetic route of 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DONG, Shuzhi; SCOTT, Jack, D.; TANG, Haiqun; ZHAO, Zhiqiang; YANG, Dexi; XIAO, Li; GU, Xin; JIANG, Jinlong; (85 pag.)WO2019/135920; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem