Synthetic Route of 17231-50-4,Some common heterocyclic compound, 17231-50-4, name is 3-Amino-6-chloro-2-pyrazinecarbonitrile, molecular formula is C5H3ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 19a (3 g, 20 mmol) in DCM (50 mL) at 0 C was successively added TiCl4(2.2 mL, 20 mmol) and tert-butyl nitrite (7.4 mL, 62 mmol). The reaction mixture was stirred at room temperature for 3 h. When the reaction was completed monitored by TLC, the solvent was evaporated and the residue was treated with water (50 mL) and then extracted with ethyl acetate (2 × 50 mL). The extract was dried over Na2SO4,and concentrated to give 8 as a white solid (2.8 g, yield 81%). 3,6-Dichloropyrazine-2-carbonitrile (8) Yield: 81%, white solid, M.p.: 93-94 C (Lit. 90-91 C,Li 2017). 1H NMR (400 MHz, CDCl3): delta 8.60 (s, 1H). 13CNMR (125 MHz, CDCl3):delta 149.82, 147.65, 147.03, 128.90,112.60. EI-MS m/z: 173 (M+, Cl35,Cl35,100), 175 (M+, Cl35,Cl37,65), 177 (M+, Cl37,Cl37,10).
The synthetic route of 17231-50-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Guo, Qi; Xu, Mingshuo; Guo, Shuang; Zhu, Fuqiang; Xie, Yuanchao; Shen, Jingshan; Chemical Papers; vol. 73; 5; (2019); p. 1043 – 1051;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem