Related Products of 5900-13-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5900-13-0 name is 5-Bromo-3-methoxypyrazin-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5-Bromo-3-methoxy-pyrazin-2-ylamine (A) (816 mg, 4 mmol) and phenyl boronic acid (732 mg , 6 mmol) in toluene (5 mL), ethanol (5 mL) and Na2CO3 (8 mmol, 1 M aqueous) was purged with nitrogen for 10 minutes, and was added PdCl2(PPh3)2 (140 mg, 0.2 mmol). The reaction mixture was stirred at 85 0C for 4 hours. The reaction mixture was cooled to room temperature and diluted with EtOAc (50 mL). The solution was washed with brine (2 X 5 mL). The organic extracts was dried with MgSO4, then solvent was removed under vacuum. The residue was purified with flash column to give product B (660 mg, 82%) as yellow solid. 1H NMR (400 MHz, CDCl3): delta 8.08 (IH, s), 7.92 (2H, d), 7.46 (3H, m), 4.94 (2H, bs), 4.12 (3H, s); MS: 202 (M + H+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-3-methoxypyrazin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; WO2008/73305; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem