Application of 126069-70-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126069-70-3, name is 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 800 mg (4.18 mmol) of 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[l,2-ojpyrazine, 3.36 g of sulfur, and 4 mL of pyridine was stirred at reflux for 3 days and then concentratedto dryness. The residue was triturated with some chloroform to remove impurity and then purified byflash chromatography on silica gel (98:2:0.2 dichloromethane:methanol:concentrated ammoniumhydroxide followed by 97:3:0.3 dichloromethane:methanol:concentrated ammonium hydroxide) to givethe title compound as a yellow-orange solid. LC-MS 222 (M+l).
The chemical industry reduces the impact on the environment during synthesis 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK & CO., INC.; WO2006/23750; (2006); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem