Adding a certain compound to certain chemical reactions, such as: 136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 136927-64-5, Computed Properties of C7H5ClN2
4-Bromo-3-methylphenol (0.26 g, 1.4 mmol), 1-chloropyrrolo[1,2- a]pyrazine (0.16 g, 1.1 mmol), and cesium carbonate (0.69 g, 2.14 mmol) were combined in dimethyl sulfoxide (5 mL), and the reaction mixture was degassed withnitrogen for 5 minutes. After it had been heated to 120 00 for 3 hours, the reaction mixture was cooled to room temperature and allowed to stand for 12 hours, whereupon it was diluted with ethyl acetate, then filtered through diatomaceous earth. The filter pad was rinsed with ethyl acetate, and the combined filtrates were washed with 1:1 water I saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered, andconcentrated in vacuo. Purification using silica gel chromatography afforded the product (344 mg) containing some impurities (-60% purity). This material was used without further purification. LCMS m/z 303.0 [M+H].
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Reference:
Patent; PFIZER INC.; GRAY, David Lawrence Firman; DAVOREN, Jennifer Elizabeth; DOUNAY, Amy Beth; EFREMOV, Ivan Viktorovich; MENTE, Scot Richard; SUBRAMANYAM, Chakrapani; WO2015/166370; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem