Electric Literature of 2727-13-1, A common heterocyclic compound, 2727-13-1, name is 3-Amino-6-chloropyrazine-2-carboxylic acid, molecular formula is C5H4ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3-amino-6-chloro-pyrazine-2-carbox-ylic acid (26.0 mg; 0.150 mmol), the amine intermediateIX.3 (100 mg; 0.151 mmol), TETU (53.0 mg; 0.165 mmol),triethylamine (63.2 jtl; 0.450 mmol) and DMF (5.0 ml) isstirred at tt. overnight. Volatiles are evaporated and theresidue is purified by RP-HPLC (Cl 8; water-ACN-TFA).10130] C25H33C1N7O5SxC2O2F3 ESI Mass spectrum_mlz=590 [M+H]+10131] HPLC analytics: RT=0.42 mm (HPLC method D)
The synthetic route of 2727-13-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Boehringer Ingelheim International GmbH; HECKEL, Armin; HAMPRECHT, Dieter; KLEY, Joerg; WIEDENMAYER, Dieter; (29 pag.)US2017/50992; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem