Some common heterocyclic compound, 723286-80-4, name is tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate, molecular formula is C10H15BrN4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 723286-80-4
3-Bromo-5,6-dihydro-8H-[l,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert- butyl ester (54.8 mg, 0.181 mmol), 4-(( ^)-3-mo holin-4-yl-l-phenylsulfanyl-methyl- propylamino)-3-trifluoromethanesulfonyl-benzenesulfonamide ( 100 mg, 0.181 mmol), (IS, 25)-N,N’-dimethyl-cyclohexane-l,2-diamine (07.71 mg, 0.054 mmol), cesium carbonate (100 mg, 0.307 mmol), and copper (I) iodide (5.16 mg, 0.027 mmol) were added to a microwave vial followed by toluene (2 mL). The reaction mixture was degassed for 15 minutes under nitrogen and then heated to 90C for 14 hours. The crude material was directly purified via flash chromatography on silica gel (0-25% 7 N ammonia in methanol in CH2C12) to afford the title compound (130 mg, 92% yield). MS [m/z; (M+l)+]: 776.5
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 723286-80-4, its application will become more common.
Reference:
Patent; NOVARTIS AG; MILLER-MOSLIN, Karen; TOURE, Bakary-Barry; VISSER, Michael Scott; YUSUFF, Naeem; WO2011/29842; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem