These common heterocyclic compound, 21948-70-9, name is 2-Methylthiopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 21948-70-9
In this example, N-heterocycles such as thiomethylpyrazine and isoquinoline were reacted with iPr2NBEt3 ยท Met bases generating the organoborate intermediates which were subsequently reacted in Suzuki type cross-coupling reactions furnishing the corresponding substituted N-heterocycles 6h-j as shown in Scheme 8a and Table 4.Scheme 8aAs shown in Scheme 8a, the substrate is reacted with the base to form a metallic organoborate intermediate. The metallic organoborate intermediate is reacted with the electrophile identified in Table 4 to form the respective products by cross-coupling the metallic organoborate intermediate with the Ar-Br electrophile (0.8 equiv) and ZnCl2 (10 mol%) in the presence of Pd(OAc)2 (3 mol%) and S-Phos (6 mol%) at 50C for 12 hours. All reactions were conducted in THF. The results are shown in Table 4 below. Table 4: Functionalization of N-heterocycles using iPr2NBEt3-derived bases6j : 79
The synthetic route of 2-Methylthiopyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HAAG, Benjamin; WO2012/85169; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem