In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. category: Pyrazines
Example 30 Preparation of 6-bromo-N-(4-(4-(oxetan-3-yl)piperazin-l-yl)phenyl)imidazo[l,2- a]pyrazin-8-amine [0268] To 4-(4-(oxetan-3-yl)piperazin-l-yl)aniline (2.00 g, 8.57 mmoles), hunig’s base (3.29 mL) and 6,8-dibromoimidazo[l,2-a]pyrazine (2.37 g, 8.57 mmoles) was added in dimethylformamide (43 mL). The reaction was stirred at 85C in a pressure tube for overnight. The material was quenched with saturated sodium bicarbonate, extracted with methylene chloride (120 mL x 3), the organic layers were combined and washed with water (120 mL x 3), dried over anhydrous sodium carbonate and concentrated. The crude material was purified using a 120 g Isco column and eluted off using a stepwise gradient of 0-60% (10% methanol / methylene chloride). The desired fractions were combined and concentrated to provide the title compound as a light yellow solid.
The synthetic route of 63744-22-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GILEAD CONNECTICUT, INC.; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; HALCOMB, Randall; KROPF, Jeffrey, E.; LEE, Seung, H.; LI, Jiayao; LO, Jennifer, R.; MITCHELL, Scott, A.; SCHMITT, Aaron; WU, Qiaoyin; XIONG, Jin-min; XU, Jianjun; ZHAO, Zhongdong; CHANDRASEKHAR, Jayaraman; LANSDON, Eric; WO2013/188856; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem