Related Products of 17231-51-5, The chemical industry reduces the impact on the environment during synthesis 17231-51-5, name is 3-Amino-6-bromopyrazine-2-carbonitrile, I believe this compound will play a more active role in future production and life.
Step A Synthesis of 2-amino-3-cyano-5-[3,5-di(trifluoromethyl)phenyl]pyrazine as an intermediate A stirred solution of 1.6 grams (0.008 mole) of 2-amino-3-cyano-5-bromopyrazine [prepared by the method of Taylor and Ray–JOC, 52, 3997 (1987)], 3.2 grams (0.012 mole) of 3,5-di(trifluoromethyl)phenylboronic acid commercially available or prepared by the method of Thompson and Gaudino–JOC, 49, 5237 (1984)], 4.3 grams (0.031 mole) of potassium carbonate and 0.3 gram of tetrakis(triphenylphosphine)palladium(0) in 150 mL of toluene is heated at 90 C. for about 20 hours. After this time, the reaction mixture is stirred with 100 mL of water, and the organic layer is separated. The organic layer is concentrated under reduced pressure to a residue. The residue is subjected to column chromatography on silica gel. The product-containing fractions are combined and concentrated under reduced pressure, yielding 2-amino-3-cyano-5-[3,5-di(trifluoromethyl)phenyl]pyrazine.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-6-bromopyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FMC Corporation; US5521190; (1996); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem