Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4858-85-9, name is 2,3-Dichloropyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 4858-85-9
[00295] Step A: 4-(3-Chloropyrazin-2-yl)-l-naphthonitrileA mixture of 2,3-dichloropyrazine (2.98g, 2mmol), 4-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)-l-naphthonitrile (0.558mmol, 2mmol) palladium tetrakis triphenylphoshine (0.069g, 0.06mmol) and aqueous sodium carbonate solution (2M, 3mL, 6mmol) in dioxane (7mL) was heated to 80C for 12 hours. The reaction mixture cooled to room temperature, washed with water, extracted with ethyl acetate and purified by chromatography to yield 4-(3-chloropyrazin-2-yl)-l-naphthonitrile (0.36g, 68%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ARDEA BIOSCIENCES, INC.; OUK, Samedy; VERNIER, Jean-michel; GUNIC, Esmir; CHEN, Chixu; WO2011/159839; (2011); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem