In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54013-07-9, name is 5-Methoxypyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C5H7N3O
2-Amino-5-methoxypyrazine (1.5 g, 12.0 mmol; CASNo. 54013-07-9) was dissolved in anhydrous THF under nitrogen and cooled in a dry ice-acetone bath. To this solution was added pyridine (2.3 mL, 28.8 mmol). After 30 min phenyl chloroformate ( 1.7 mL, 13.2 mmol) was added dropwise. The reaction mixture was allowed to gradually warm to room temperature. After 2 hours ethyl acetate (90 mL) and water (45 mL) were added. The aqueous layer was back extracted once with ethyl acetate. The combined organic layers were washed twice with brine, then dried (MgSO4), filtered and concentrated. The residue was triturated with ether: ethyl acetate (50 mL: 2 mL). The solid was collected by vacuum filtration and washed with ether. To give the title compound as a pale yellow solid (2.5 g, 10.1 mmol, 85%) 1H NMR (400 MHz, DMSO-Cf6) delta ppm 10.79 (s, 1 H), 8.58 (s, 1H), 8.13 (s, 1 H), 7.36-7.52 (m, 2H), 7.16-7.34 (m, 3H), 3.88 (s, 3H). m/z 246.1
The synthetic route of 54013-07-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; WO2009/127949; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem