Month: May 2021

Reference of 123-32-0, The chemical industry reduces the impact on the environment during synthesis 123-32-0, name is 2,5-Dimethylpyrazine, I believe this compound will play a more active role in future production and life.

Preparation of 3,6-dimethyl-2- (4-methoxy) benzoyl pyrazine, comprising the steps of: (1) 2,5-dimethyl pyrazine take 0.2mmol, 4- methoxybenzoyl acid 0.4mmol, 0.02 mmol silver phosphate, potassium persulfate 5mL reaction tube was placed 0.4mmol, 1.4mL was added di methylene chloride, 0.6 mL of distilled water was added, and the mixture was placed in an oil bath at 40 heated, reaction 24h, cooled to room temperature to obtain a reaction solution;(2) The step (1) the resulting reaction mixture was directly concentrated to give a concentrate, the concentrate with ethyl acetate / petroleum ether = 1/2 (v / v) as the developing solvent, separation by thin layer chromatography to give 56mg target The product, in 80% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dimethylpyrazine, other downstream synthetic routes, hurry up and to see.

Related Products of 69214-33-1, These common heterocyclic compound, 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N-Bromosuccinimide (2.0 g, 11.6 mmol) was added to a stirred solution of intermediate 3 (1.78 g, 11.58 mmol) in DCM (50 ml). The mixture was stirred at RT for 2 h. and then diluted with further DCM and washed with a saturated solution of sodium carbonate. The organic layer was separated, dried (Na2S04), filtered and the solvent evaporated in vacuo to yield a 72/28 mixture of 3-bromo-8-chloro-imidazo[l,2-a]- pyrazine and 3,8-dibromo-imidazo[l,2-a]pyrazine (intermediate 15) (5.89 g, 99%) as white solid.

Statistics shows that 8-Chloroimidazo[1,2-a]pyrazine is playing an increasingly important role. we look forward to future research findings about 69214-33-1.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C5HCl2N3

Example 1 (R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(quinolin-3-ylamino)pyrazine-2-carboxamide A solution of 3,5-dichloropyrazine-2-carbonitrile (348 mg, 2.00 mmol), D-leucinamide hydrochloride (333 mg, 2.00 mmol) and DIEA (1.00 mL, 5.75 mmol) in NMP (8 mL) was stirred at room temperature for 20 h. Water and EtOAc were added. Organic phase was separated, dried over Na2SO4, concentrated in vacuo to give (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-4-methylpentanamide as an oil (535 mg).

The synthetic route of 313339-92-3 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 330786-09-9, name is Methyl 3,5-dichloropyrazine-2-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 330786-09-9, HPLC of Formula: C6H4Cl2N2O2

Methyl 3,5-dichloropyrazine-2-carboxylate (2.83 g,13.7 mmol), palladium acetate (302 mg, 1.33 mmol), 4,5-bis(diphenylphosphino)-9,9- dimethylxanthene (1.63 g, 2.82 mmol), potassium carbonate (18.5 g, 135 mmol), and tert- butyl 3-amino-5-methyl-lH-pyrazole-l-carboxylate (2.70 g, 13.7 mmol) were suspended in anhydrous dioxane (95 mL). The resulting mixture was degassed with nitrogen for5 minutes and stirred at 90C for one hour. The reaction was partitioned between ethyl acetate and water. The aqueous layer was extracted with ethyl acetate (3 x 200 mL), and the organic layers were combined and dried over magnesium sulfate. After filtration, the solvent was removed in vacuo. The residue was purified by silica gel chromatography (0-60% ethyl acetate in hexanes) to give the title compound as a yellow solid (4.2Og, 11.42 mmol, 84% yield); IH NMR (400 MHz, DMSO-^6) delta ppm 1.55 (s, 9 H), 2.21 (s, 3 H), 3.86 (s, 3 H), 6.66 (s, 1 H), 8.57 (s, 1 H), 10.43 (s, 1 H); MS (ESI) m/z 368.3 [M+l]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, A new synthetic method of this compound is introduced below., category: Pyrazines

1-(3,5-Dichloro-pyrazin-2-yl)-ethanone (2.2 g), prepared as described in example 10, and (4-tert-butoxycarbonyl-aminophenyl)boronic acid (2.7 g), was added to a reaction vessel containing a magnetic stirring bar together with 1,1′-bis(diphenylphosphino)ferrocene-palladium(II) dichloride (674 mg) and cesium carbonate (11.2 g), followed by 100 ml dioxane and 10 ml water, and the mixture heated to 100C under stirring. After 1 h the reaction mixture was cooled to RT and quenched with a saturated aqueous sodium bicarbonate solution (50 ml) and extracted with EtOAc (3 x 100 ml). The combined organic phases were dried over sodium sulfate, filtered and evaporated to afford the crude product as a dark brown oil. Purification by flash chromatography on silica gel using a mixture of EtOAc and heptane as the eluent afforded [4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-carbamic acid tert-butyl ester as a colorless solid after evaporation of the solvents under reduced pressure. Yield: 2.44g (61 %) mg.

The synthetic route of 313339-92-3 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H6BrN3O2

General procedure: Aryl halide, palladium(II) bis(triphenylphosphine) dichloride or (triphenylphosphine) palladium (0.05eq), boronic acid or pinacol ester (1.1 eq) and cesium fluoride (2 eq) were weighed out into a microwave vessel or sealed tube. Ethanol (3 mL/mmol) and water (0.6 mL/mmol) were added. The vessel was capped and heated thermally or in a microwave vessel at 70-100 C. for 1 hour. The reaction mixture wasconcentrated under vacuum and the residue was purified by silica gel columnchromatography to afford the Suzuki coupling product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6966-01-4.

Related Products of 179323-60-5,Some common heterocyclic compound, 179323-60-5, name is 1-(Pyrazin-2-yl)ethanamine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2 5-Iodo-4′-methyl-biphenyl-3-carboxylic acid-1-pyrazin-2-yl-ethyl)-amideThe 5-iodo-4′-methyl-biphenyl-3-carboxylic acid from step 1, together with 1-pyrazin-2-yl-ethylamine (0.15 mL, excess), HOAt (10 mg, catalytic amount), NMM (0.4 mL) and EDCI (400 mg) were added to DMF (6 mL). The reaction mixture was stirred overnight at room temperature, then partitioned between water and ethyl acetate. The organic layer was concentrated under reduced pressure and the resulting residue was purified by preparative thin layer chromatography (5% MeOH in dichloromethane) to give 340 mg (95% yield overall) of 5-iodo-4′-methyl-biphenyl-3-carboxylic acid 1-pyrazin-2-yl-ethyl)-amide.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(Pyrazin-2-yl)ethanamine, its application will become more common.

Related Products of 77112-52-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 77112-52-8 name is Ethyl imidazo[1,2-a]pyrazine-2-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of lithium chloride monohydrate (6.50g, 0.156mol) was added to Compound 84 (9.73g, 0.05mol) [Reference Preparation WO2009090055] in ethanol / water (400ml / 100ml), stirred at room temperature 8 hours, the solvent was distilled off under reduced pressure, under ice-cooling with a 1N aqueous hydrochloric acid solution was adjusted to PH 3-4, and the precipitated solid was filtered, washed with acetone and dichloromethane, respectively cake, 50 C and dried under reduced pressure to give a pale pink solid powder compound 85, a total of 7.69g (9.4mmol), yield 93.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl imidazo[1,2-a]pyrazine-2-carboxylate, and friends who are interested can also refer to it.

Application of 110223-15-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110223-15-9, name is 2-Amino-3-benzyloxypyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

3-(benzyloxy)pyrazin-2-amine (100 mg, 0.5 mmol) and 2-fluoro isocyanate (0.67 mL, 0.60 mmol) in tetrahydrofuran (0.25 M) was dissolved in 8 hours during the heating under reflux thereby. After completion of the reaction, and concentrating the solvent under reduced pressure. The residue was washed with methanol and vacuum filter to give 122.6 mg of the desired compound in a yield of 69.43%.

The synthetic route of 2-Amino-3-benzyloxypyrazine has been constantly updated, and we look forward to future research findings.

Synthetic Route of 32974-92-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 32974-92-8, name is 1-(3-Ethylpyrazin-2-yl)ethanone belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Example 2602-(N-bis-hydroxyethyl)aminoethyl-3-ethyl-2-pyrazylketone 8733 2-acetyl-3-ethylpyrazine (148 mg), diethanol amine (119 mg), and paraformaldehyde (40 mg) were reacted at 130 C. for 2 hours.NMR (CDCl3) 1.31 (t, 3H), 2.75 (m, 43H), 3.25 (m, 2H), 3.71 (m, 2H), 3.80 (M, 2H), 4.0 (m, 2H), 8.2 (s, 1H), 8.25 (s, 1H)TG 76.3 (3 mumol) 45.2 (10 mumol) 10.2 (30 mumol)SOCE 0 (10 mumol) 0 (30 mumol) 0 (100 mumol)IICR 20 (10 mumol) 0 (30 mumol) 20 (100 mumol)

The synthetic route of 1-(3-Ethylpyrazin-2-yl)ethanone has been constantly updated, and we look forward to future research findings.