Month: May 2021

Application of 313340-08-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 313340-08-8, name is 3,5-Dichloro-6-ethylpyrazine-2-carboxamide belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Compound D1Sa (100 mg, 0.455 mmol), A1Sf (109 mg, 0.499 mmol) and DIPEA (117 mg, 0.909 mmol) were dissolved in 1,4-dioxane (3 mL) in a sealed tube, the reaction mixture was heated to 130 C. and stirred for 16 hours. The LCMS indicated the reaction was complete, the reaction mixture was concentrated in vacuo, the residue was purified via column chromatography (DCM/MeOH=30:1) to afford a pale yellow solid compound D1Sb (160 mg, yield 88%). 1H NMR (DMSO-d6, 400 MHz) delta 10.93 (s, 1H), 8.21 (s, 1H), 7.98 (s, 1H), 7.14 (d, J=2.0 Hz, 1H), 6.93-6.82 (m, 2H), 4.23 (dd, J=10.8 Hz, 2.8 Hz, 1H), 3.90 (dd, J=10.4 Hz, 9.2 Hz, 1H), 3.66 (d, J=11.6 Hz, 1H), 3.05-2.95 (m, 1H), 2.89-2.74 (m, 4H), 2.65-2.55 (m, 1H), 2.22 (s, 3H), 2.13-2.03 (m, 1H), 1.68 (dd, J=10.8 Hz, 10.8 Hz, 1H), 1.24 (t, J=7.4 Hz, 3H). MS m/z 403.2 [M+H]+, 405.2 [M+H]+.

The synthetic route of 3,5-Dichloro-6-ethylpyrazine-2-carboxamide has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56423-63-3, name is 2-Bromopyrazine, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromopyrazine

General procedure: A Schlenk tube was charged with the prescribed amount of catalyst, aryl halide (1.0 mmol), 3-(hydroxymethyl)phenylboronicacid (1.5 mmol), TBAB (1.0 mmol), the selected base (3.0 mmol), and water under nitrogen atmosphere. The reaction mixture was heated at 100 C for 12 h. After cooling,the mixture was extracted with CH2Cl2, the solvent was evaporated,and the product was separated by passing through a silica gel column with CH2Cl2/ethyl acetate (5:1) aseluent. The products 2f, 2j, 2l, and 2o were new compounds and were determined by 1H and C13 NMR. Other products were characterized by comparison with data in the literature.

The synthetic route of 56423-63-3 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 108-50-9 as follows. Formula: C6H8N2

EXAMPLE 107 alpha,alpha’-Dichloro-2,6-dimethylpyrazine A stirred mixture of 2,6-dimethylpyrazine (55 mmol), N-chlorosuccinimide (110 mmol) and benzoylperoxide (1.0 mmol) in carbon tetrachloride (150 mL) is heated to reflux under nitrogen for 30 hours. Additional N-chlorosuccinimide (140 mmol) and benzoylperoxide (2.3 mmol) are added at 6 hours. The cooled reaction mixture is filtered and the filtrate washed with sodium carbonate (saturated aqueous solution) and dried. Evaporation of the solvent gives the title compound.

According to the analysis of related databases, 108-50-9, the application of this compound in the production field has become more and more popular.

Application of 19847-12-2,Some common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, molecular formula is C5H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of pyrazine-2-carbonitrile (1.0 g, 9.52 mmol) in methanol (20 mL) was addedNaOCH3 (0.10 g, 1.90 mmol). The resulting mixture was heated with stirring at rt for 12 hrs. Tothe reaction mixture was added NH4C1 (0.51 g, 9.52 mmol). After being heated under reflux for 3 hrs, the resulting reaction mixture was concentrated in vacuo. The residue was suspended in ethanol (30 mL). The suspension was heated under reflux for 1 hr, then cooled to rt and filtered. The filtrate was concentrated in vacuo to give pyrazine-2-carboxamidine hydrochloride (1.2 g),which was used in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazinecarbonitrile, its application will become more common.

Related Products of 14508-49-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14508-49-7 as follows.

In air, a vial was charged with complex Ih (6.8 mg, 0.01 mmol), potassium carbonate (207 mg, 1.50 mmol), the boronic acid (0.6 mmol) and the organohalide (0.5 mmol). The vial was sealed with a septum and purged with argon (3×). Dioxane (2.0 mL) was added and the contents were stirred at 60 C. for the specified period of time. The reaction was then diluted with diethyl ether (2 mL) and transferred to a round bottom flask. The reaction vial was rinsed with additional diethyl ether (2 mL) and combined with the previous dilution. Each reaction was performed in duplicate and the contents were combined, concentrated onto silica gel and purified by flash chromatography.

According to the analysis of related databases, 14508-49-7, the application of this compound in the production field has become more and more popular.

Electric Literature of 109838-85-9, These common heterocyclic compound, 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution containing 0.62 mL (650 mg, 3.53 mmol) of Schoellkopf’s reagent in 10 mL of anhydrous THF at -78 °C was added 0.45 mL (308 mg, 4.82 mmol) of 2.5 M BuLi. The reaction mixture was stirred at -78 °C for 30 min under argon and then a solution containing 1.03 g (3.21 mmol) of 3-(chloromethyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (4) in 10 mL of anhydrous THF was added. The reaction mixture was stirred for 1 h under argon at -78 °C, then diluted with 50 mL of satd aq NH4Cl and extracted with two 50-mL portions of EtOAc. The combined organic phase was dried (MgSO4) and concentrated under diminished pressure. The residue was purified by chromatography on a silica gel column (10 * 2 cm). Elution with 2:1 hexanes/ethyl acetate gave 3-(((2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl)methyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (5) as a yellow oil: yield 783 mg (52percent); silica gel TLC Rf 0.15 (4:1 hexanes/ethyl acetate); 1H NMR (CDCl3, 400 MHz) delta 0.51(d, 3H, J = 6.8 Hz), 0.78 (d, 3H, J = 8 Hz), 1.99-2.03 (m, 1H), 2.22 (s, 3H), 3.07-3.12 (m, 3H), 3.57 (s, 3H), 3.60 (s, 3H), 4.22-4.25 (m, 1H), 7.02-7.05 (m, 1H), 7.13 (d, 1H, J = 8 Hz), 7.36 (s, 1H), 7.74 (dd, 1H, J = 8.0 and 1.6 Hz), 7.87 (d, 2H, J = 8.4 Hz) and 8.29 (dd, 1H, J = 4.8 and 1.6 Hz); 13C NMR (CDCl3, 400 MHz) delta 16.4, 18.8, 21.5, 29.1, 31.3, 52.1, 52.3, 55.5, 60.4, 114.9, 118.3, 123.7, 124.6, 127.5, 128.2, 129.5, 135.5, 144.6, 144.8, 147.1, 161.8 and 164.0; mass spectrum (APCI), m/z 469.1921 (M+H)+ (C24H29N4O4S requires m/z 469.1909).

The synthetic route of 109838-85-9 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 313340-08-8, name is 3,5-Dichloro-6-ethylpyrazine-2-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3,5-Dichloro-6-ethylpyrazine-2-carboxamide

Preparation Example 29 To a mixture of tert-butyl 3-hydroxypyrrolidine-1-carboxylate (1 g) and N,N-dimethylformamide (30 mL) was added 55% oily sodium hydride (233 mg) under ice-cooling. After stirring for 30 minutes under ice-cooling, 3,5-dichloro-6-ethylpyrazine-2-carboxamide (1.18 g) was added thereto, followed by further stirring for 1 hour under ice-cooling. The reaction mixture was poured into ice water, followed by extraction with ethyl acetate. The organic phase was washed with saturated brine and then dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (eluent: chloroform) to obtain tert-butyl 3-[(5-carbamoyl-6-chloro-3-ethylpyrazin-2-yl)oxy]pyrrolidine-1-carboxylate (795 mg) as a pale yellow solid.

The synthetic route of 3,5-Dichloro-6-ethylpyrazine-2-carboxamide has been constantly updated, and we look forward to future research findings.

Related Products of 1060814-53-0, A common heterocyclic compound, 1060814-53-0, name is (5-Chloropyrazin-2-yl)methanamine, molecular formula is C5H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 254 4-N-[(5-chloropyrazin-2-yl)methyl]-6-(2,3-dimethylphenyl)pyrimidine-2,4-diamine. 4-Chloro-6-(2,3-dimethylphenyl)pyrimidin-2-amine (12 mg, 0,050 mmol), (5- chloropyrazin-2-yl)methanamine (14 mg, 0, 10 mmol), Et3N (0,040 mL, 0,30 mmol) and 1-butanol (0,20 mL) were stirred at 100C for 20 hours. MeOH (1 mL) was added and the mixture was purified by preparative HPLC to give the desired product. LCMS [M+H]+ 341.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 3-amino-6-bromopyrazine-2-carboxylate

General Method 9Preparation of (S)-(2-(3-chlorobenzyl)pyrrolidin-1-yl)(3-hydroxy-6-phenylpyrazin-2-yl)methanone (9-6); Step 1: Methyl 3-amino-6-bromopyrazine-2-carboxylate 9-1 (0.85 g, 3.68 mmol), phenylboronic acid (0.56 g, 3.68 mmol) and 2M aqueous sodium carbonate (7.4 mL) were mixed with toluene (8 mL) and methanol (2 mL). Palladium tetrakis(triphenylphosphine) (427 mg, 0.37 mmol) was added. The mixture was degassed and heated under nitrogen at 85 C. for 4 h. The reaction mixture was cooled to room temperature and filtered through a pad of Celite. The filtrate was concentrated and residue was separated by column chromatography (silica gel, gradient elution with DCM to 5% MeOH-DCM), to give desired product 9-2 as a yellow solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 1458-01-1, A common heterocyclic compound, 1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, molecular formula is C6H7ClN4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3,5-Diamino-6-chloropyrazine-2-carboxylic acid A mixture of methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (100 g; 494 mmol), methanol (1 l) and NaOH (6 mol/l in water; 240 ml; 1.44 mol) is refluxed for 3 h. The mixture is allowed to cool to r.t. and then neutralized by addition of hydrochloric acid (6 mol/l in water; approx. 240 mL). Water (200 ml) is added. The precipitate formed is filtered off with suction, washed with water and dried at 60° C. C5H5ClN4O2 ESI Mass spectrum: m/z=189 [M+H]+; m/z=187 [M-H]-

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.