Month: May 2021

These common heterocyclic compound, 312736-49-5, name is 3,5-Dichloropyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 312736-49-5

To a solution of 55A (10 g, 51.82 mmol) and HATU (21.67 g, 57 mmol) in DMF (50 mL), DIEA (19.86 mL, 1 14 mmol) was added. After 30 minutes, Nu,Omicron-dimethylhydroxylamine hydrochloride (6.09 g, 62.18 mmol) was added to the solution. The mixture was stirred for overnight. Water (300 mL) was added and extracted with EtOAc three times (100 mL). The crude product purified by flash chromatography to afford the desired product. MS (m/z) 236 [M+H]+.

The synthetic route of 3,5-Dichloropyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Related Products of 875781-43-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Method BSteplIn a dry round-bottomed flask, 2-bromo-5H-pyrrolo[2,3-b]pyrazine (5.0 g, 25.2 mmol) was dissolved in DMF (50 mL). The reaction mixture was cooled to 0C and sodium hydride (60% dispersion in mineral oil, 1.22 g, 30.6 mmol). The reaction mixture was warmed to room temperature and stirred for 15 min then cooled back to 0C and SEM-C1 (5.4 mL, 30.4 mmol) was slowly added. After the addition was complete, the ice bath was removed and the reaction mixture was stirred at room temperature for 1.5 h. The reaction mixture was quenched with 50 mL water and extracted with 150 mL diethyl ether (2x). The combined organic layers were washed twice with 30 mL water and once with 30 mL brine then dried over sodium sulfate, filtered and concentrated. The residue was absorbed on -20 g Si02 and chromatographed over 200g Si02 with EtOAc/Hexanes (gradient: 0-15% EtOAc). All fractions containing product were combined and concentrated to afford 6.61 g (80%) of 2- bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine as a pale yellow oil which gradually solidified.

The synthetic route of 2-Bromo-5H-pyrrolo[2,3-b]pyrazine has been constantly updated, and we look forward to future research findings.

Synthetic Route of 63744-22-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To 4-(4-(oxetan-3-yl)piperazin-l-yl)aniline II (2.00 g, 8.57 mmoles), hunig’s base (3.29 mL) and 6,8-dibromoimidazo[l,2-a]pyrazine (2.37 g, 8.57 mmoles) was added in DMF (43 mL). The reaction was stirred at 85 C in a pressure tube for overnight. The material was quenched with saturated sodium bicarbonate, extracted with DCM (120 mL x 3) and the organic layers were combined and washed with water (120 mL x 3), dried over anhydrous sodium carbonate and concentrated. The crude material was purified using a 120 g Isco column and eluted off using a stepwise gradient of 0-60% (10% MeOH/DCM). The desired fractions were combined and concentrated to provide the title compound III.

The synthetic route of 6,8-Dibromoimidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 5049-61-6

To a solution of 2-amino pyrazine (20 g, 210 mmol) in dimethoxy ethane (400 ml) was added ethyl bromopyruvate (32.8 ml) at 25 C. and the resulting reaction mixture was allowed to stir at the same temperature for 4 hrs. It was then cooled to 0 C. and stirred for 30 minutes. The separated solid was filtered and washed with ether. Solid residue was taken in ethanol (1000 ml) and refluxed for 4 hrs. Solvent was removed completely, residue taken in chloroform (1000 ml), saturated sodium bicarbonate solution (700 ml) was added to it and the mixture was allowed to stir for 45 minutes. The mixture was filtered through celite bed, washed several times with chloroform and filtrate was dried over sodium sulfate. Evaporation of the organic layer under reduced pressure gave the crude mass, which was purified by crystallization using ether-methanol mixture. Yield: 20%

According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-Amino-3,5-dibromopyrazine

To a 1000 mL single-necked round bottom flask was added 2-amino-3,5-dibromopyrazine (43.18 g, 220 mmol), chloroacetaldehyde (77.72 g, 396 mmol) and DMF 550 mL. The mixture in the reaction flask was stirred at 80 C for 8.5 hours. TLC and GC confirmed the reaction was complete. After the reaction was completed, the solvent was removed by rotary evaporation to give a crude product, which was purified by silica gel column chromatography to obtain the pure product 6,8-dibromoimidazo [1,2a] pyrazine. After drying, the yield was 83.71% and the purity was 99.00% (HPLC

According to the analysis of related databases, 24241-18-7, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 2-aminopyrazine-3-carboxylate

Step B. Methyl 3-f [4-(dimethylamino)-1-naphthoyl]amino(at)pyrazme-2-carboxylate; Oxalyl chloride (1.70 mL, 19.5 mmol) was added to a solution of 4-(dimethylamino)- I – naphthoic acid (2.63 g, 12.2 mmol) in DCE (125 mL) at 0°C. The reaction mixture was allowed to warm to ambient temperature, heated to 85°C and stirred for 10 min. The reaction mixture was evaporated to dryness and the red residue was suspended in DCE (30 mL). The resulting suspension was added drop wise via a pump syringe over 7 hrs. to a solution of methyl 3-aminopyrazine-2-carboxylate (1.25 g, 8.16 mmol) and pyridine (4.75 mL, 58.7 mmol) in DCE (125 mL) at 80°C. The reaction mixture was stirred for 10 hrs at 80°C, cooled to ambient temperature and washed with 0.1M HCl solution. The solvent was concentrated and the product was purified on silica gel by MPLC to provide the title compound as white solid (1.24 g, 43 percent)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 1458-18-0

Example 68[0291] A suspension of methyl 3-amino-5,6-dichloro-2-pyrazinecarboxylate (5.0 gm, 2.25 X 10~2 moles) in 2-propanol (50 mL) was stirred asN-methylpiperazine (2.48 gm, 2.48 X 10~2 moles) was added. To this mixture was added diisopropyethylamine (3.2 gm, 2.48 X 10″2 moles) after which the reaction was heated to reflux. At reflux, a brown solution resulted. After 2 hours at reflux, TLC (silica, 10% methanol in methylene chloride) showed all of the starting material had been consumed with the formation of a single product. The reaction was cooled to room temperature overnight which caused the product to crystallize. The solid product was isolated by filtration and was washed with 2-propanol and then with diethyl ether. After drying there was obtained 5.8 gm (90.2%>) of the product as a pink solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 54608-52-5, The chemical industry reduces the impact on the environment during synthesis 54608-52-5, name is 2-Hydrazinopyrazine, I believe this compound will play a more active role in future production and life.

Example-4: Preparation of Selinexor (0507) (0508) (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1 H-1 ,2,4-triazol-1 -yl)acrylic acid (10 g) was combined with a mixture of acetonitrile (1 00 mL) and ethyl acetate (50 mL) then added the 2-hydrazinylpyrazine (3.76 g) and stirred for 5 min. Reaction mixture was cooled to 0C and diisopropyl ethyl amine (16.63 ml) and then Propylphosphonic anhydride (T3P, 33.31 mL) was added at 0C and stirred the reaction mixture for 2.5 hours at the same temperature. After completion of the reaction, the reaction mixture was quenched with cold water (100 mL) and extracted the product with ethyl acetate (2 x 150 mL). The combined organic layer was dried over sodium sulphate and evaporated the solvent under vacuum at 40C to obtain the crude product as yellow syrup. The obtained crude product was combined with dichloromethane (1 00 mL) and filtered the solid and washed with dichloromethane (2 x 50 mL). The solid was dried under vacuum at 40C to obtain the title compound with purity by HPLC of 99.86%. Yield : 7 g

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Hydrazinopyrazine, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 6863-74-7, name is 6-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6863-74-7, SDS of cas: 6863-74-7

To a suspension of 349 Raney-Ni (307 mg, 3.59 mmol,) in 25 EtOH (20 mL) was added 350 6-chloropyrazine-2-carbonitrile (1.00 g, 7.17 mmol,) and 351 tert-butoxycarbonyl tert-butyl carbonate (1.72 g, 7.88 mmol), then the reaction mixture was stirred at room temperature under H2 (45 psi) for 16 hours. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to give a residue. The residue was purified by flash silica gel chromatography (eluention with 010% 56 Ethyl acetate/Petroleum ether gradient) to give 352 tert-butyl N-[(6-chloropyrazin-2-yl)methyl]carbamate (1.05 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Chloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Related Products of 123-32-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123-32-0, name is 2,5-Dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows.

Preparation of 3,6-dimethyl-2-benzoylpyrazine, include the following steps: (1) Take 0.2 mmol 2,5-dimethyl pyrazine, 0.4mmol benzoyl formate, silver phosphate 0.02 mmol, 5mL of potassium persulfate was placed 0.4mmol reaction tube, was added 1.4mL of dichloromethane, 0.6 mL of distilled water to form a mixture, and the reaction was placed in an oil bath at 40C reaction was heated 24h, cooled to room temperature to obtain;(2) The step (1) the resulting reaction mixture was directly concentrated to give a concentrate, the concentrate with ethyl acetate / petroleum ether = 1/2 (v / v) as the developing solvent, separation by thin layer chromatography to give 40mg target The product, 95% yield.

The chemical industry reduces the impact on the environment during synthesis 2,5-Dimethylpyrazine. I believe this compound will play a more active role in future production and life.