Month: May 2021

Electric Literature of 33332-25-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Description 22 1,1-Dimethylethyl 7-((5-[(methyloxy)carbonyl]-2-pyrazinyl}oxy)-1,2,4,5-tetrahydro-3H- 3-benzazepine-3-carboxylate (D22); Sodium hydride (800 mg of 60% dispersion; 20 mmol) was added to a solution of 1,1- dimethylethyl 7-hydroxy-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (5 g; 19 mmol; obtainable by the process described in Description 3 from WO 02/40471) in dry dimethylformamide (40 ml) and the reaction stirred at room temperature for 45 minutes. Methyl 5-chloro-2-pyrazinecarboxylate (3.9 g; 22.8 mmol) was added and the mixture stirred at room temperature for 18 hours. The mixture was poured into water and extracted with diethyl ether. The extracts were combined, dried (sodium sulphate) and evaporated. The residue was purified by silica column chromatography eluting with 2-1 hexane – ethyl acetate to afford a white powder (4.6 g; 61%) 8(CDC13) 1.49 (s, 9H), 2.92 (m, 4H), 3.58 (m, 4H), 4.01 (s, 3H), 6.94 (m, 2H), 7.18 (m, H), 8.48 (s, H), 8.84 (s, H).

The chemical industry reduces the impact on the environment during synthesis Methyl 5-chloropyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.

Reference of 1458-18-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1458-18-0 as follows.

The mixture of methyl 3-amino-5, 6-dichloropyrazine-2-carboxylate (0.5 g, 2.26 nMol) , 4, 4, 5, 5-tetramethyl-2- (5-methylfuran-2-yl) -1, 3, 2-dioxaborolane (0.71 g, 3.39 nMol) in dioxane (20 mL) was added Na 2CO 3 (0.94 g, 4.53 nMol) and Pd (dppf) Cl 2 (0.83 g, 1.13 nMol) at 100 . Then the mixture was stirred at this temperature for 2 h. LCMS showed the reaction was completed and purified with silica gel chromatography to give a desired product methyl 3-amino-6-chloro-5- (5-methylfuran-3-yl) pyrazine-2-carboxylate. LCMS: m/z (ESI) , [M+H] + = 268.4.

According to the analysis of related databases, 1458-18-0, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939412-86-9, Recommanded Product: 939412-86-9

Step 2: (0988) Preparation of N-((3-chloropyrazin-2-yl)methyl)formamide: (0989) [00368] To a stirred solution (3-chloropyrazin-2-yl)methanamine hydrochloride (0.5 g, 2.77 mmol) in dichloromethane (20 mL) and N,N-dimethyl formamide (4 mL) were added N,N-diisopropylethylamine (0.72 mL, 4.16 mmol), 1-Ethyl-3-(3- dimethylaminopropyl)carbodiimide (0.79 g, 4.16 mmol), 1-hydroxybenzotriazole (0.37 g, 2.77 mmol) , formic acid (0.135 mL, 3.60 mmol) and the reaction mixture was stirred at room temperature for 18 h. After completion of the reaction, the reaction mixture was quenched with water (50 mL) and extracted with dichloromethane (3 x 80 mL). The combined organic layer was washed with brine (40 mL), dried over anhydrous sodium sulfate and evaporated to get the crude product. The crude product was purified by silica gel column chromatography using 2% methanol in dichloromethane to afford the title compound N-((3-chloropyrazin-2- yl)methyl)formamide (0.21 g, 44% yield) as a yellow solid. Calculated (M+H): 172.0; Found (M+H): 172.1

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (3-Chloropyrazin-2-yl)methanamine hydrochloride, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 72788-94-4, name is 2-Chloro-5-(hydroxymethyl)pyrazine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H5ClN2O

Step 1. (5-(piperidin-1-yl)pyrazin-2-yl)methanolCombined (5-chloropyrazin-2-yl)methanol (500.00 mg; 3.46 mmol; 1.00 eq.), potassium carbonate (954.63 mg; 0.01 mol; 2.00 eq.) and piperidine (589.02 mg; 6.92 mmol; 2.00 eq.) in N,N-dimethylformamide (10.00 ml). Heated the reaction to 90 C. for overnight. Let the reaction cool to rt. Diluted reaction with water, extracted with ethyl acetate, combined organics, dried with MgSO4, filtered, and concentrated to give (5-(piperidin-1-yl)pyrazin-2-yl)methanol (0.67 g; 100% crude). MS (M+H)+ found for C10H15N3O: 193.6.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 72788-94-4.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Formula: C6H5ClN2O2

A mixture of methyl 3-chloropyrazine-2-carboxylate (1.0 g, 5.8 mmol), (0733) allyl tributyl stannane (7.4 g, 22 mmol) and bis(triphenylphosphine)palladium(II) di chloride (0.41 g, 0.58 mmol) in DMF (15 mL) was degassed and backfilled with nitrogen (three times), and the reaction mixture was heated to 110 C for 1.5 h. The mixture was quenched with saturated aqueous potassium fluoride, and filtered. The filtrate was extracted with EtOAc, and the combined organic layer was dried over Na2S04, filtered and concentrated. The residue was purified by silica gel column chromatography (EtOAc in hexanes) to give methyl 3- allylpyrazine-2-carboxylate. LCMS (C9HnN202+) (ES, m/z): 179 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 889447-19-2, name is 2-Chloro-5H-pyrrolo[2,3-b]pyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Chloro-5H-pyrrolo[2,3-b]pyrazine

To a stirred solution of 2-chloro-5H-pyrrolo[2,3-b]pyrazine, 3a, (1.54 g, 0.01 mol) in DMF (38 mL) was N-bromsuccinimide (1.78 g, 10.00 mmol). The mixture was stirred at room temperature for 1.5h until the reaction was complete. The mixture was poured into EtOAc and the organic layer was washed with several portions of brine. The organic layer was dried (MgS04), filtered and concentrated in vacuo. The resulting solid was triturated with Et20 to afford 1.88 g of the desired product (80% yield): XH NMR (400 MHz, d6- DMSO) delta 12.82 (s, 1H), 8.44 (d, J = 21.1 Hz, 1H), 8.25 (d, J = 2.5 Hz, 1H) ppm; LCMS Gradient 10-90%, 0.1% formic acid, 5 min, C18/ACN, RT = 2.59 min (M+H) 231.97.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 19847-12-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19847-12-2, name is Pyrazinecarbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To 20 mL of methyl alcohol is added sodium (109 mg, 4.74 mmol) with stirring. After disappearance of the solid, 2-pyrazinecarbonitrile (5.0 g, 47.6 mmol) is added. The mixture is stirred at room temperature for 6 h, and ammonium chloride (2.8 g, 52.3 mmol) is added. The mixture is then stirred at room temperature for 18 h. Diethyl ether (50 mL) is added to the reaction mixture, and the precipitates are collected by filtration. The solid was washed with diethyl ether (×2) and dried in vacuum oven to give 2-pyrazinecarboxamidine hydrochloride as a white solid (6.5 g). MS: m/z 123.1 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazinecarbonitrile, other downstream synthetic routes, hurry up and to see.

Application of 87486-34-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 87486-34-8 name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example lOld 5 -Bromo- 1 -methyl- 3 – [4- (morpholine-4-carbonyl)phenylamino] – 1H- pyrazin-2-one lOld CGIPHARM60WOlOldA 250-mL single-neck round-bottomed flask equipped with a magnetic stirrer and reflux condenser was charged with 3,5-dibromo-l-methylpyrazin-2(lH)-one (J. Heterocycl. Chem. 1983, 20, 919) (21.8 g, 81.4 mmol), 4-aminobenzmorpholide (23.6 g, 114 mmol) and dimethyl- acetamide (130 mL). The reaction mixture was then heated under nitrogen at 105 °C for 14 h (Note: A spatula was used to break up the solids formed after 4 h of heating). After this time the suspension was cooled to room temperature, poured into stirring water (1.5 L) and filtered. The resulting precipitate was washed with water (2 x 250 mL) and allowed to partially dry on the filter paper for 10-15 minutes. After this time the filter cake was washed with hot ethyl acetate (2 x 250 mL), followed by hot ethanol (250 mL) and dried under reduced pressure to afford a 63percent yield (24.3 g) of lOld as a light orange solid: mp 276-277 °C; ]H NMR (500 MHz, CDC13) delta 8.39 (bs, 1H), 7.81 (dd, 2H, / = 9.0, 2.0 Hz), 7.45 (dd, 2H, J = 9.0, 2.0 Hz), 6.81 (s, 1H), 3.71 (m, 8H), 3.55 (s, 3H); MS (ESI+) m/z 393 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromo-1-methylpyrazin-2(1H)-one, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines

Example 331a 5-Bromo-1-methyl-3-(3-methylisothiazol-5-ylamino)pyrazin-2(1H)-one 331a A sealed tube equipped with a magnetic stirrer was charged with 3-methylisothiazol-5-amine (170 mg, 1.5 mmol), 3,5-dibromo-1-methylpyrazin-2(1H)-one (400 mg, 1.5 mmol), Pd(OAc)2 (84 mg, 0.375 mmol), BINAP (116 mg, 0.188 mmol), K2CO3 (450 mg, 4.5 mmol), and 1,4-dioxane (4 mL). After three cycles of vacuum/nitrogen flush, the mixture was heated at 120°C in a sealed tube for 18 h. It was then cooled to room temperature and filtered. The filtrate was evaporated under reduced pressure. The residue was purified by silica-gel column chromatography eluting with dichloromethane/methanol (100:1 to 25:1) to afford 331a (220 mg, 50percent) as a yellow solid. MS-ESI: [M+H]+ 301.0.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 87486-34-8.

Related Products of 19847-12-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19847-12-2, name is Pyrazinecarbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

(1) preparing a format reagent,Add magnesium, anhydrous polarity to a nitrogen-protected pressure vesselSolvent tetrahydrofuran and elemental iodine, then add methyl chloride to the pressure vessel and stir.After the pressure vessel is heated to 60 C and stirring is continued for 2 hours, a format reagent is prepared;Metal magnesium is newly formed magnesium, and the molar ratio of magnesium metal to chloromethane acid is 1:1.1;The content of elemental iodine is 0.21% × metal magnesium weight; the reaction equation is as follows:(2)Addition reaction, adding 2-cyanopyrazine and tetrahydrofuran to the reactor and heating the reactor to50 C, then add catalysisThe cuprous chloride and the reagents of the above format are then refluxed and condensed.After the end, the remaining part of the reactor is an intermediate product, wherein the addition reaction time is 14h;The molar ratio of 2-cyanopyrazine to the format reagent S1 is1:1.05; the content of cuprous chloride is 2.1% metal magnesium weight;(3)Hydrolyzing, adding water to the remaining intermediate product of the above reactor,The pH of the solution in the reactor was adjusted to 1 with dilute sulfuric acid, and then stirred for 12 hours.Adjusting the pH of the solution in the reactor to neutral with a saturated aqueous solution of sodium carbonate;Finally extracted with toluene three times;(4)After the treatment, the toluene extract is desolvated, and the solid after desolvation is dissolved by heating with ethanol.Add activated carbon, continue heating and reflux for 10 min, and filter.The filtrate was cooled to 5 C to obtain a white solid P1; then the white solid P1 was recrystallized from ethanol.Produced a white solid P2,Drying gives 2-acetylpyrazine;The purity of 2-acetylpyrazine was 98.4%, and the yield of 2-acetylpyrazine was 69%.The reagent polar solvents, elemental iodine, 2-cyanopyrazine, tetrahydrofuran toluene and ethanol were all analytically pure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazinecarbonitrile, other downstream synthetic routes, hurry up and to see.