Month: May 2021

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 73627-18-6 as follows. Product Details of 73627-18-6

Example 1 (6-chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(1-methyl-3,4-dihydro-1H-pyrrolo[ 1,2-a]pyrazin-2-yl)-methanone A solution of 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (181 mg, 0.92 mmol, 1.0 equiv), 1-methyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine (150 mg, 1.10 mmol, 1.2 equiv), EDC (176 mg, 0.92 mmol, 1.0 equiv) and HOAt (125 mg, 0.92 mmol, 1.0 equiv) in DMF (5 mL) was heated at 50C for 4 h. The mixture was allowed to cool to room temperature and poured into water and extracted with ethyl acetate. The combined organic layers were washed three times with brine, dried over Na2SO4 and concentrated. The residue was subjected to flash column chromatography (40% ethyl acetate in heptane) to yield 265 mg (91 %) of the title compound in good to moderate yield. LC/MS: m/z = 317 (MH+)

According to the analysis of related databases, 73627-18-6, the application of this compound in the production field has become more and more popular.

Synthetic Route of 77168-85-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77168-85-5, name is Methyl 5-chloro-6-methylpyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Step 1: methyl 5-(5-fluoro-2-methoxypyridin-4-yl)-6-methylpyrazine-2-carboxylate To a nitrogen-purged solution of methyl 5-chloro-6-methylpyrazine-2-carboxylate (15 g, 80 mmol), (5-fluoro-2-methoxypyridin-4-yl)boronic acid (16.49 g, 96 mmol), Pd (dppf) Cl2 dichloromethane adduct (1.2 g,1.469 mmol) and Pd(dppf)C12 (4.6 g, 6.29 mmol) in THF (199 ml) and water (40.8 ml) was addedpotassium phosphate tribasic (51.2 g, 241 mmol) under a nitrogen atmosphere. A reflux condenserwas attached and the mixture was vigorously refluxed with a 100 °C oil bath with stirring. After 105mm, the reaction was cooled to rt and partitioned between EtOAc (200 mL) and water (200 mL).The layers were separated and the aqueous layer was extracted with ethyl acetate (150 mL). Theorganic layers were combined, filtered through C eliteTM, washed with brine, dried over anhydrousMg504, filtered and evaporated to afford a crude residue. The resulting residue was purified via column chromatography on silica gel (ISCO RediSep Gold 330g silica gel column, gradient elution with 0percent to 50percent EtOAc in hexanes) to give the title compound.

The chemical industry reduces the impact on the environment during synthesis Methyl 5-chloro-6-methylpyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.

1057216-55-3, name is 2-Chloro-5-iodopyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-Chloro-5-iodopyrazine

Intermediate 31 (350 mg, 1.05 mmol), 2-chloro-5-iodopyrazine (252 mg, 1.05 mmol), 2M aqueous sodium carbonate solution (1.58 mL, 3.16 mmol) and anhydrous DMSO (5 mL) were charged to a sealed tube. The mixture was degassed by bubbling with nitrogen for 5 minutes before the addition of tetrakis(triphenylphosphine)20 palladium(0) (61 mg, 0.05 mmol). The reaction mixture was sealed under nitrogen andstirred at 110C for 1 h. The mixture was diluted with water (40 mL) and extracted with EtOAc (3 x 20 mL). The organic phase was washed with saturated aqueous sodium bicarbonate solution (2 x 10 mL) followed by brine (10 mL), then dried over sodium sulfate and concentrated under vacuum. The residue was purified by FCC, eluting with17-80% EtOAc in heptane, to afford the title compound (285 mg, 54% at 80% purity) as an off white solid. oH (500 MHz, CDC13) 8.73-8.64 (m, 2H), 8.63-8.59 (m, 1H), 7.92 (s, 2H), 7.33-7.27 (m, 1H), 7.17 (d, J8.2 Hz, 1H), 7.15-7.07 (m, 1H), 7.00 (d, J6.6 Hz, 1H),6.67 (t, J73.5 Hz, 1H), 4.36 (s, 2H), 2.60 (s, 3H). Method C HPLC-MS: MH+ m/z 401,

The synthetic route of 1057216-55-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1220330-11-9, name is 5-Ethoxypyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 1220330-11-9

5-Ethoxypyrazine-2-carboxylic acid (53.9 mg, 320 muiotaetaomicron) was suspended in dichloromethane (5 mL), the suspension was cooled to 0-5C (ice bath) and oxalyl chloride (56.9 mg, 39.3 mu, 448 muiotaetaomicron) as well as dimethylformamide (0.308 M in toluene, 51.9 mu, 16 muiotaetaomicron) were added. The mixture was stirred for 1.5 h at room temperature. Then, it was concentrated in vacuo (40C, 5 mbar) and dried azeotropically by two cycles of addition of toluene (3 mL) followed by concentration in vacuo to afford 5-ethoxypyrazine-2-carbonyl chloride as yellow oil (59.7 mg, quant.). After that, tert-butyl ((3aS,4R,8R)-4-(5-amino-2-fluorophenyl)-4,7,7-trimethyl-8-oxido- 3,3a,4,7-tetrahydro-2H-isothiazolo[l,5-a] [l,4]thiazin-6-yl)carbamate (Int- 16ABp, 80 mg, 188 muiotaetaomicron) was dissolved in dichloromethane (5 mL), the solution cooled to 10C and N,N- diisopropylethylamine (36.5 mg, 49.4 mu, 283 muiotaetaomicron) was added, followed by a solution of 5- ethoxypyrazine-2-carbonyl chloride (vide supra, 47.7 mg, 256 muiotaetaomicron) in dichloromethane (4 mL). The reaction mixture was stirred for 15 min at 10C. Then, methanol (2 mL) was added, the mixture was stirred for 5 min at room temperature and concentrated in vacuo. The crude was purified by column chromatography (silica gel, 24 g, eluting with 2 M ammonia in methanol / dichloromethane, gradient 1 :99 to 3:97) to yield, after drying in vacuo (40C, 5 mbar), the title compound as a white solid (92 mg, 85% yield). HPLC (method LCMS_fglm) tR = 1.37 min. MS (ES+) m/z 575.4 [M+H] .

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 213019-67-1, name is 3-(Trifluoromethyl)pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H4F3N3

A solution of bromine in dichloromethane (1 OmI) was added in portions to a stirred solution of 2-amino-3-trifluoromethylpyrazine (1 .5g, 9.2mmol) and pyridine (0.90m1, limmol) in chloroform. The resulting mixture was stirred at room temperature for 24hours. Volatiles were removed under reduced pressure and the residue was purified by chromatography on silica gel using a gradient of ethyl acetate in isohexane as eluent to give 2-am ino-3-trifluoromethyl-5-bromopyrazine (1 .7g, 77% yield) as an off-white solid.1H NMR (400 MHz, CDCI3)5 8.30 (s, 1H), 5.13 (br s, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 213019-67-1.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25773-40-4, name is 2-Isopropyl-3-methoxypyrazine, A new synthetic method of this compound is introduced below., COA of Formula: C8H12N2O

Photocatalytic experiments were carried out in a solar sim-ulator Atlas Suntest XLS+ (Germany). Illumination was providedwith a xenon lamp (2.2 kW) which was jacketed with special fil-ters restricting the transmission of wavelengths below 290 nm.Irradiation experiments were performed using a Pyrex glass UV-reactor containing 250 mL of aqueous solutions and the appropriateamount of TiO2(100 mg L-1) at natural pH. The suspension was keptin the dark for 30 min, prior to illumination to reach adsorptionequilibrium onto semiconductor surface. A relatively low amountof TiO2(100 mg L-1) and a higher initial concentration of IPMP(10 mg L-1) than the typical values found in drinking waters havebeen selected in the experiments in order to obtain slower kineticsand provide favorable conditions for the identification and struc-tural elucidation of transformation products and the mineralizationstudy.

The synthetic route of 25773-40-4 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 73627-18-6, name is 1,2,3,4-Tetrahydro-1-methylpyrrolo[1,2-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73627-18-6, HPLC of Formula: C8H12N2

Synthesis of 4-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-oxobutanoic acid S4 A solution of (190 mg, 1.4 mmol) of 1-methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (A21) in THF (10 ml) was added dropwise in the course of 30 min to a suspension of (558 mg, 5.6 mmol) of succinic anhydride in THF (10 ml). The mixture was then stirred for 2 h at RT and concentrated in vacuo. The residue was taken up in chloroform, washed with water and brine, dried over MgSO4 and concentrated in vacuo. 257 mg (0.92 mmol, 54%) of 4-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-oxobutanoic acid (S4) were obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2,3,4-Tetrahydro-1-methylpyrrolo[1,2-a]pyrazine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 717847-03-5, name is 6-Morpholinopyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 717847-03-5, Safety of 6-Morpholinopyrazin-2-amine

5,7-Difluoro-3-methyl-2-(4-methylpyridin-2-yl)-N-(6-morpholinopyrazin-2- yl)quinolin-4-amineThe Buchwald coupled product was prepared according to Procedure H using of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (0.025 g, 0.053 mmol), 6-morpholinopyrazin-2-amine (0.071 g, 0.39 mmol), 4-chloro-5,7-difluoro-3- methyl-2-(4-methylpyridin-2-yl)quinoline (0.1 g, 0.33 mmol) and Pd2dba3 (0.012 g, 0.013 mmol) and sodium tert-butoxide (0.079 g, 0.82 mmol) in toluene (3.3 mL) at 100 C for 48.5 h. The crude product was purified by columnchromatography on alumina (0 to 60% EtOAc in hexanes) to yield the desired product 5,7-difluoro-3-methyl-2-(4-methylpyridin-2-yl)-N-(6-morpholinopyrazin-2-yl)quinolin-4-amine. .H NMR (400 MHz, CD2C12) delta ppm 8.55 (1 H, d, J=5.1 Hz), 7.64 – 7.67 (1 H, m), 7.59 (1 H, s), 7.54 (1 H, ddd, J=9.6, 2.5, 1.4 Hz), 7.38 (1 H, s), 7.17 – 7.26 (2 H, m), 7.02 (1 H, ddd, J=13.3, 8.8, 2.5 Hz), 3.69 – 3.76 (4 H, m), 3.39 – 3.46 (4 H, m), 2.47 (3 H, s), 2.26 (3 H, s). Mass Spectrum (ESI) m/e = 449.1 (M + 1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Electric Literature of 2882-21-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2882-21-5 as follows.

To a solution of 2-methoxy-6-methylpyrazine (21.3 g, 171.6 mmol) mAcOH (150 mL)was added NaBO2 H202 3H20 (31.7 g, 205.9 mmol). The mixture was stirred at 80C for 16 hours. The mixture was cocentrated in vacuo and diluted with 2 M aq. NaOH (300 mL). The mixture was extracted with EtOAc (200 mL x 4). The organic layer was washed with brine (100 mL), dried over Na2SO4 and concentrated in vacuo to give 3-methoxy-5-methylpyrazine1-oxide (14.4 g, 60% yield).

According to the analysis of related databases, 2882-21-5, the application of this compound in the production field has become more and more popular.

Related Products of 29094-61-9, A common heterocyclic compound, 29094-61-9, name is Glipizide, molecular formula is C21H27N5O4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Glipizide (445.5 mg, 1.0 mmol) was dissolved in DMSO (anhydrous, 10ML). Sodium amide (76.03mg, 2. 0 mmol) was then added. The reaction mixture was stirred at room temperature for 10 min. DTPA-dianhydride (357.32 mg, 1.0 mmol) was dissolved in DMSO (anhydrous, 10ML). Sodium amide (76.03 mg, 2.0 mmol) was then added. The reaction mixture was stirred at room temperature for 10 min. DTPA-dianhydride (357.32 mg, 1.0 mmol) dissolved in 5 ml DMSO (anhydrous) was added and the mixture was stirred for 4 hours. The mixture was added with water (10 mL), followed by 1N-sodium hydroxide solution (3 mL) and stirred for 2 hours. The solid was filtered and washed with water. This recovered starting material was 142.6 mg (32%) after drying under vacuum. The aqueous phase was dialyzed with membrane (MW CO < 500) for 2 days. DTPA-GLP (506.6 MG, ; 61.7% yield) as a white solid was gathered after lyophilization. The synthetic scheme is shown in Figure 8. Figures 9-17 SHOWED LH-, L3C-NMR spectrum and assignment and mass spectrometry of DTPA-glipizide. The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.