Month: May 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-61-9, name is 6-Methylpyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., category: Pyrazines

General procedure: Under argon, a stirred solution of appropriate carboxylic acid (0.37 mmol, 1.0 eq.) and Et3N (0.48 mmol, 1.3 eq.) in dry THF (7 mL) was cooled to -10 °C. Ethyl chloroformate (0.55 mmol, 1.5 eq.) was dropwise added and the resulting mixture was stirred for 2 h. Afterward, a solution of sodium azide (0.63 mmol, 1.7 eq.) in water (2 mL) was added in one portion. After 1 h at -10 °C, the reaction was found to be complete (TLC) and was quenched into iced water (5 mL). The mixture was extracted with EtOAc (3 * 10 mL) and the combined organic layers were successively dried over MgSO4, filtered and evaporated under reduced pressure. The crude acyl azide was placed in dry toluene (20 mL) and the mixture heated at reflux for 1 h to give the corresponding crude isocyanate. The latter was dissolved in dry dioxane (7 mL) prior to adding the amine 4 (0.37 mmol, 1.0 eq.). The solution was heated at reflux for 24 h. The reaction mixture was cooled to room temperature and the volatiles were removed to dryness in vacuum at 40 °C. The dark residue was purified by silica gel chromatography column (CH2Cl2/MeOH 99/1) to afford the desired valmerins.

The synthetic route of 5521-61-9 has been constantly updated, and we look forward to future research findings.

Electric Literature of 127406-08-0,Some common heterocyclic compound, 127406-08-0, name is 4-(Pyrazin-2-yl)benzaldehyde, molecular formula is C11H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound from step A (6.2 g, 33.5 mmole), (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (22.6 g, 52.7 mmole), tris[2-(2-methoxyethoxy)ethyl]amine (11.2 ml, 34.9 mmole), sat. aq. K2CO3 (150 mls), and CH2Cl2 (150 ml) were heated at reflux for 17 hours. The mixture was cooled and the aqueous layer was washed with CH2Cl2 (2×). The combined organic layers were washed with NaHCO3, brine, dried (MgSO4), and concentrated.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Pyrazin-2-yl)benzaldehyde, its application will become more common.

Related Products of 5910-89-4, The chemical industry reduces the impact on the environment during synthesis 5910-89-4, name is 2,3-Dimethylpyrazine, I believe this compound will play a more active role in future production and life.

A mixture of 2,3-dimethylpyrazine (2Og, 18.5mmol), selenium dioxide (41.06g, 37mmol) and diatomeous earth (2Og) in EtOAc (500ml) was stirred and heated at 7O0C for 2 hours. The mixture was allowed to cool and the insoluble matter was removed by filtration EPO through diatomeous earth. The filtrate was washed with saturated aqueous sodium hydrogen carbonate solution and then saturated aqueous sodium chloride solution, dried (MgSO4) and the solvent removed by evaporation. The residue was suspended in water (100ml) and hydroxylamine (45ml of a 50% aqueous solution) was added. The mixture was stirred at ambient temperature for 18 hours and the mixture then extracted with EtOAc. The extracts were combined, washed with saturated aqueous sodium chloride solution, dried (MgSO4) and the solvent removed by evaporation. The residue was triturated with isohexane to give 3- methylpyrazine-2-carboxaldehyde oxime (9.65g, 38%); NMR Spectrum 2.67 (s, 3H), 8.23 (s, IH), 8.45-8.49 (m, 2H), 11.87 (s, IH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dimethylpyrazine, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1250996-70-3, name is tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C12H19N3O3

[0090] Method B-Step g: Preparation of tert-butyl 2-(morpholinomethyl)-5,6- dihydroimidazo[l,2-a]pyrazine-7(8H)-carboxylate [0091] To a solution of tert-butyl 2-(hydroxymethyl)-5,6-dihydro imidazo[l,2-a]pyrazine- 7(8H)-carboxylate (400 mg, 1.579 mmol) and triethylamine (320 mg, 3.158 mmol) in CH2C12 (4 mL) was added methanesulfonyl chloride (199 mg, 1.737 mmol) dropwise at 0 C. The mixture was stirred at room temperature for 30 minutes. TLC showed the reaction was complete. The reaction mixture was poured into 10 mL of ethyl acetate and washed with water (3 mL) twice. The organic layer was dried over Na2S04 and concentrated in vacuo, then dissolved in DMF (8 mL) with K2CC>3 (395 mg, 3.98 mmol), then morpholine (347 mg, 3.98 mmol) was added. The mixture was stirred at 100 C for 2 hours. TLC showed that the reaction was complete. The reaction mixture was portioned between ethyl acetate (20 mL) and water (5 mL), washed with brine (5 mLx3). The organic layer was concentrated under reduced pressure, purified by silica gel column chromatography (CH2Cl2:MeOH = 50:1 ) to give a brown oil (220 mg, 51.43%). *H NMR (400 MHz, CDC13) delta 6.75 (s, 1H), 4.67 (s, 2H), 3.94 (d, / = 2.6 Hz, 2H), 3.83 (s, 2H), 3.74 (m, 7=4.4 Hz, 4H), 3.45 (s, 2H), 2.53 (s, 4H), 1.48 (s, 9H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1250996-70-3.

Related Products of 66490-61-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 66490-61-7, name is 3,5,6-Tribromopyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: [0268] In a mixture of 3,5,6-tribromopyrazin-2-amine (146 mg, 0.5 mmol), triethylamine (202 mg, 2 mmol), and catalytic amount of DMAP (5 mol %) in dry CH2CI2 (5 mL) was added 3- fluorobenzoylchloride (176 mg, 1 mmol) at room temperature. The mixture was stirred at room temperature overnight, and concentrated under reduced pressure. The residue was then dissolved in MeOH (5 mL) and K2CO3 (100 mg) was added. The mixture was stirred at 60 C for 1 h. The mixture was then reduced down and the product purified via silica chromatography (ethyl acetate:hexanes).

The synthetic route of 3,5,6-Tribromopyrazin-2-amine has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 168123-82-8, name is 7-Bromopyrido[2,3-b]pyrazine-2,3(1H,4H)-dione, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 168123-82-8, COA of Formula: C7H4BrN3O2

General procedure: A mixture of substituted pyridine-2,3-diamine 1 (20 mmol) anddiethyl oxalate(10 mL) was stirred at 100 C for 12 h and cooled toroom temperature subsequently. Ethoxyethane was added toobtain solid. The formed solid was then centrifuged and dried toobtain brown solid compound of pyrido[2,3-b]pyrazine-2,3(1H,4H)-dione 2. The mixture of pyrido[2,3-b]pyrazine-2,3(1H, 4H)-dione and POCl3(20 ml) was stirred at 130 C and then cooled toroom temperature. The mixture was poured into the ice water. Theformed solid was filter and then evaporated solvent in vacuo toobtain unpurified 2,3-dichloropyrido[2,3-b]pyrazine 3. Then theunpurified was mixture with LiOH (10 mmol) in THF/H2O (5:2,35 mL). The mixture was stirred at 65 C for 12 h. The resultingmixture was cooled to room temperature, and then brine (10 mL)was added to mixture. After extraction with THF (3 50 ml), thecombined organic layers were washed with brine (30 mL), dried over anhydrous MgSO4, and filtered, followed by evaporation of thesolvent in vacuo to obtain the unpurified 2-chloropyrido[2,3-b]pyrazin-3(4H)-one 4a-c. The crude products were purified by columnchromatography on silica gel using petroleum ether/EtOAc(3:1) as eluent to provide the desired product 2-chloropyrido[2,3-b]pyrazin-3(4H)-one derivatives4a-c.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Bromopyrido[2,3-b]pyrazine-2,3(1H,4H)-dione, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 70838-55-0, name is 2-Chloropyrido[2,3-b]pyrazine, A new synthetic method of this compound is introduced below., category: Pyrazines

EXAMPLE 6 STR36 A mixture of 2-chloro-pyrazino[2,3-b]pyridine (3.35g), isopropanol (20 mL) and concentrated ammonium hydroxide (50 mL) was heated at 115 C. for 17 h in a sealed tube. The tube was cooled and the product was collected and recrystallized from ethanol to afford 2-amino-pyrazino[2,3-b]pyridine as a yellow solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 43029-20-5, These common heterocyclic compound, 43029-20-5, name is 3-Amino-6-methylpyrazin-2(1H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE H3 3-Amino-1,6-dimethylpyrazin-2-one (Compound 14.12) 8.87 g of dimethyl sulfate are added dropwise to a mixture of 8.13 g of 3-amino-6-methylpyrazin-2-one and 72 ml of 1N sodium hydroxide solution at room temperature. After the mixture has been stirred at 20-25 C. for 15 hours, the precipitate is filtered off, the filtrate is concentrated to one quarter of the volume and the concentrate is extracted with ethyl acetate. 1.7 g of 3-amino-1,6-dimethylpyrazin-2-one with a melting point of 217-219 C. are obtained by washing with saturated sodium chloride solution, drying with sodium sulfate and concentrating the organic phase.

The synthetic route of 43029-20-5 has been constantly updated, and we look forward to future research findings.

Reference of 38557-71-0, These common heterocyclic compound, 38557-71-0, name is 2-Chloro-6-methylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 2-chloro-6-methylpyrazine (24 g, 186.7 mmol) in anhydrous MeOH (240 mL) was added NaOMe (12.1 g, 224 mmol). The mixture was stirred at 60-70C for 16hours. The mixture was cooled and filtered. The filtrate was concentrated in vacuo to give 2- methoxy-6-methylpyrazine (22 g, 95% yield). 1H NMR (CDCI3400 MHz): 7.98 (s, 1H), 7.94(s, 1H), 3.91 (s, 3H), 3.40 (s, 3H). LC-MS: tR = 1.47 mm (method 14), mlz= 124.8 [M + H].

Statistics shows that 2-Chloro-6-methylpyrazine is playing an increasingly important role. we look forward to future research findings about 38557-71-0.

1250996-70-3, name is tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of tert-Butyl 2-(hydroxymethyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate

To a solution of 2-hydroxymethyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester (IV, 0.34 g, 1.34 mmol) in dry methanol (12 mL) was added 20% HQ in dioxane (18 mL) at 0 C and the resulting mixture was stirred at room temperature for 16 h. The solvent was evaporated under reduced pressure to get the crude product which was triturated with diethylether to afford the titled product as a pale-yellow solid (V, 0.25 g, 95 %). LC-MS m/z calcd for C7HuN30, 153.1 ; found 154.2 [M+H]+.

The synthetic route of 1250996-70-3 has been constantly updated, and we look forward to future research findings.