Reference of 912773-24-1, These common heterocyclic compound, 912773-24-1, name is 6-Bromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : To a solution of 6-bromoimidazo[l,2-a]pyrimidine (2.4 g, 12.1 mmol) in DMF, were sequentially added (4-methylpiperazin-r-yl)(4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenyl)methanone (80% of 4.1 g, 12.1 mmol), a solution of NaHC03 (3.1g, 36.3 mmol) in water (30 mL), water (3 mL) and (A-Phos)2PdCl2 (400 mg, 0.60 mmol). The reaction mixture was heated at 90 C for 4 h, then was diluted with water (100 mL) and extracted with EtOAc (3><100 mL). The combined organic layer was dried over Na2S04, filtered and concentrated under reduced pressure.. The residue was purified by flash column chromatography (silica gel, eluent CHCl3/MeOH 95 :5 to 85 : 15) to afford of (4-(imidazo[ 1 ,2-a]pyrazin-6-yl)phenyl)(4- methylpiperazin-l-yl)methanone (1.5 g, 65%). 1H NMR (400 MHz, CDC13) delta 8.60 (d, J~ 2,0 Hz, 1 H), 8.10 (d, J= 4.0, 1 H), 7.80 (d, J= 8.0 Hz, 1 H), 7.58 (m, 4 H) 7.39 (d, J= 8.0, 1 H), 3.84 (br s, 2 H), 3.50 (br s, 2 H), 2.40 (br s, 4 H), 2.35 (s, 3 H); MS (ESI) m/z 322 [M+1]
Statistics shows that 6-Bromoimidazo[1,2-a]pyrazine is playing an increasingly important role. we look forward to future research findings about 912773-24-1.
Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao; WO2013/147711; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem